Department of Demography and Geodemography, Faculty of Science, Charles University, Prague, Czechia.
Department of Obstetrics and Gynaecology, Second Faculty of Medicine, Charles University, Prague, Czechia.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024 Nov;168(4):332-341. doi: 10.5507/bp.2023.039. Epub 2023 Oct 3.
The aim of this study is to determine whether the risk of preterm births differs according to the conception method: with or without ART and according to the ART method used (in-vitro fertilisation (IVF) with fresh embryo transfer, frozen embryo transfer (FET) and oocyte receipt (OoR)).
The research is based on individualised anonymised data on deliveries in Czechia in 2013-2018 (n=651,049) obtained from the National Health Information System. We employ the survival analysis approach applying survival functions (Life tables method) and Cox regression to model the risk of preterm births according to the conception method when controlling for a set of covariates.
The results revealed that the risk of preterm births in singleton pregnancies is higher for ART-treated women (1.56 to 2.06 depending on the ART method) than for non-ART-treated women. The proportion of preterm births differs according to the ART method; the highest proportion was observed for OoR mothers.
Overall, the differences between ART-treated mothers according to the conception method are due mainly to the structural differences between mothers. When controlling for the covariates (Cox regression model), no significant differences were observed concerning the risk of preterm births for women who underwent fresh IVF, FET and OoR.
本研究旨在确定早产的风险是否因受孕方式（有无辅助生殖技术[ART]以及所使用的 ART 方法）而异，这些方法包括新鲜胚胎体外受精（IVF）移植、冷冻胚胎移植（FET）和卵母细胞接收（OoR）。
该研究基于 2013-2018 年捷克全国健康信息系统中获取的个体化匿名分娩数据（n=651049）。我们采用生存分析方法，应用生存函数（寿命表法）和 Cox 回归模型，在控制了一系列协变量的情况下，根据受孕方式来模拟早产的风险。
结果显示，ART 治疗的女性（取决于 ART 方法，1.56 至 2.06）比未接受 ART 治疗的女性发生早产的风险更高。根据 ART 方法，早产的比例也有所不同，OoR 母亲的比例最高。
总体而言，受孕方式不同的 ART 治疗母亲之间的差异主要归因于母亲的结构差异。在控制协变量（Cox 回归模型）后，接受新鲜 IVF、FET 和 OoR 的女性早产的风险无显著差异。
