Zeng Weiwei, Zhang Hanjie, Yuan Xue, Chen Ting, Pei Zhengcun, Ji Xiaoyuan
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin 300072, China; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China.
Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.
Adv Drug Deliv Rev. 2022 May;184:114241. doi: 10.1016/j.addr.2022.114241. Epub 2022 Mar 31.
Two-dimensional nanomaterial-based catalytic medicines that associate the superiorities of novel catalytic mechanisms with nanotechnology have emerged as absorbing therapeutic strategies for cancer therapy. Catalytic medicines featuring high efficiency and selectivity have been widely used as effective anticancer strategies without applying traditional nonselective and highly toxic chemodrugs. Moreover, two-dimensional nanomaterials are characterized by distinctive physicochemical properties, such as a sizeable bandgap, good conductivity, fast electron transfer and photoelectrochemical activity. The introduction of two-dimensional nanomaterials into catalytic medicine provides a more effective, controllable, and precise antitumor strategy. In this review, different types of two-dimensional nanomaterial-based catalytic nanomedicines are generalized, and their catalytic theories, advanced catalytic pathways and catalytic nanosystem design are also discussed in detail. Notably, future challenges and obstacles in the design and further clinical transformation of two-dimensional nanomaterial-based catalytic nanomedicine are prospected.
将新型催化机制的优势与纳米技术相结合的二维纳米材料基催化药物，已成为引人关注的癌症治疗策略。具有高效性和选择性的催化药物已被广泛用作有效的抗癌策略，而无需使用传统的非选择性且剧毒的化学药物。此外，二维纳米材料具有独特的物理化学性质，例如可观的带隙、良好的导电性、快速的电子转移和光电化学活性。将二维纳米材料引入催化药物中，提供了一种更有效、可控且精确的抗肿瘤策略。在这篇综述中，概括了不同类型的二维纳米材料基催化纳米药物，并详细讨论了它们的催化理论、先进的催化途径和催化纳米系统设计。值得注意的是，还展望了二维纳米材料基催化纳米药物在设计和进一步临床转化方面未来面临的挑战和障碍。
