Department of Emergency Internal Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Genoxor Medical Science and Technology Inc., Shanghai, China.
Front Cell Infect Microbiol. 2023 Sep 20;13:1249225. doi: 10.3389/fcimb.2023.1249225. eCollection 2023.
is the causative agent of psittacosis in humans, while its rapid identification is hampered due to the lack of specificity of laboratory testing methods.
This study reports four cases of infection after contact with a domestic parrot, all belonging to the same family. Common manifestations like fever, cough, headache, nausea, and hypodynamia appeared in the patients. Metagenomic next-generation sequencing (mNGS) aided the etiological diagnosis of psittacosis, revealing 58318 and 7 sequence reads corresponding to in two cases. The detected was typed as ST100001 in the Multilocus-sequence typing (MLST) system, a novel strain initially reported. Based on the results of pathogenic identification by mNGS, the four patients were individually, treated with different antibiotics, and discharged with favorable outcomes.
In diagnosing psittacosis caused by a rare agent, mNGS provides rapid etiological identification, contributing to targeted antibiotic therapy and favorable outcomes. This study also reminds clinicians to raise awareness of psittacosis when encountering family members with a fever of unknown origin.
鹦鹉热衣原体是人类鹦鹉热的病原体，由于实验室检测方法缺乏特异性，其快速鉴定受到阻碍。
本研究报告了 4 例接触家养鹦鹉后感染鹦鹉热衣原体的病例，均属于同一家庭。患者出现发热、咳嗽、头痛、恶心和乏力等常见症状。宏基因组下一代测序（mNGS）有助于鹦鹉热的病因诊断，在 2 例中分别检测到 58318 和 7 个序列读取与鹦鹉热衣原体相对应。在多位点序列分型（MLST）系统中，检测到的鹦鹉热衣原体被分型为 ST100001，这是一种最初报道的新型菌株。基于 mNGS 的致病鉴定结果，4 名患者分别接受了不同的抗生素治疗，最终均康复出院。
在诊断由罕见病原体引起的鹦鹉热时，mNGS 可快速进行病因鉴定，有助于针对性的抗生素治疗和良好的预后。本研究还提醒临床医生在遇到不明原因发热的家庭成员时，要提高对鹦鹉热的认识。
