Yan Xinsheng, Fu Huali, Deng Wenjun, Zhang Zhenlu, Wang Dong
Department of Clinical Laboratory, Wuhan Asia General Hospital, Wuhan Asia General Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
Respiratory and Critical Care Medicine, Wuhan Asia General Hospital, Wuhan Asia General Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
Front Med (Lausanne). 2024 Nov 27;11:1491838. doi: 10.3389/fmed.2024.1491838. eCollection 2024.
Psittacosis is a zoonotic infectious disease caused by () infection, which can be transmitted by birds, poultry and wild animals. The symptoms and imaging findings of pneumonia are atypical and primarily rely on etiological diagnosis. The incidence of infection has been significantly underestimated because of the low sensitivity and poor timeliness of traditional diagnostic methods. Therefore, early and accurate diagnosis of psittacosis remains a challenge.
A case series with six pneumonia patients who were admitted to our hospital in the period from January 2023 to June 2023 is presented. These patients exhibited acute onset and symptoms, including fever, cough, poor appetite, dry mouth, dizziness, chills, and chest tightness. Despite comprehensive laboratory and radiological examinations, the cause of the pneumonia remained unidentified. Therefore, a sample of bronchoalveolar lavage fluid (BALF) was tested via target next-generation sequencing (tNGS), which revealed a positive result for . Prompt adjustment of the treatment regimens upon identification of the pathogen led to favorable outcomes in all patients.
tNGS is a novel diagnostic technology that enables rapid, accurate and cost-effective detection of pneumonia. Early detection of can improve patient outcomes through timely adjustment of therapies.
鹦鹉热是一种由（）感染引起的人畜共患传染病，可通过鸟类、家禽和野生动物传播。鹦鹉热肺炎的症状和影像学表现不典型，主要依靠病因诊断。由于传统诊断方法灵敏度低、及时性差，鹦鹉热感染的发病率一直被严重低估。因此，鹦鹉热的早期准确诊断仍然是一项挑战。
本文介绍了2023年1月至2023年6月期间我院收治的6例肺炎患者的病例系列。这些患者起病急，症状包括发热、咳嗽、食欲减退、口干、头晕、寒战和胸闷。尽管进行了全面的实验室和影像学检查，但肺炎病因仍未明确。因此，通过靶向二代测序（tNGS）检测支气管肺泡灌洗液（BALF）样本，结果显示（）呈阳性。病原体鉴定后及时调整治疗方案，所有患者均取得良好疗效。
tNGS是一种新型诊断技术，能够快速、准确且经济高效地检测鹦鹉热肺炎。早期检测出鹦鹉热可通过及时调整治疗方案改善患者预后。
