Hao Linlin, Tian Qingfen, Liu Shaohua, Xu Zhe, Yang Lixia
Department of Ophthalmology, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Otolaryngology, Jinan Second People's Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Front Med (Lausanne). 2023 Sep 20;10:1220104. doi: 10.3389/fmed.2023.1220104. eCollection 2023.
This study aimed to evaluate changes in ocular surface parameters among obstructive sleep apnea syndrome (OSAS) patients.
44 healthy volunteers (88 eyes) and 27 OSAS patients (54 eyes) were recruited in our cross-sectional study. 14 patients were classified as mild&moderate OSAS, and 13 patients were classified as severe OSAS. For evaluating the ocular surface, the following tests were conducted: the height of tear meniscus (TMH), first non-invasive tear break-up time (FNITBUT), mean non-invasive tear break-up time (MNITBUT), the score of Meibomian gland dropout area (Meiboscore), the tear test of anesthesia-free Schirmer I (SIT), corneal fluorescein staining (CFS), partial blinks rate (PBR), the lipid layer thickness (LLT), ocular surface disease index (OSDI). The results obtained from the study were analyzed and compared among the groups.
FNITBUT, MNITBUT, and TMH were lower. OSDI, CFS, Meiboscore and PBR were higher in the OSAS group than those in the control group. The mild&moderate as well as the severe OSAS subgroups had statistically significantly lower TMH, and higher OSDI and PBR than the control group. Meanwhile, we found there were no significant differences between two OSAS subgroups. CFS was higher in the severe OSAS group than the mild&moderate OSAS group. Significantly lower FNITBUT, MNITBUT and higher Meiboscore were observed in the severe OSAS subgroup than in the control group, and MNITBUT was higher in severe OSAS objects than in the mild&moderate OSAS objects. LLT and SIT did not exhibit significant differences among control and OSAS subgroups. FNITBUT and MNITBUT showed significantly negative correlations with BMI, while Meiboscore showed a significant positive correlation with AHI.
Patients with OSAS have a tendence of dry eyes, whereas control subjects do not. This indicates us that the OSAS patients should pay more attention to ocular surface care.
本研究旨在评估阻塞性睡眠呼吸暂停综合征（OSAS）患者眼表参数的变化。
在我们的横断面研究中招募了44名健康志愿者（88只眼）和27名OSAS患者（54只眼）。14名患者被分类为轻度和中度OSAS，13名患者被分类为重度OSAS。为评估眼表，进行了以下测试：泪河高度（TMH）、首次非侵入性泪膜破裂时间（FNITBUT）、平均非侵入性泪膜破裂时间（MNITBUT）、睑板腺缺失面积评分（Meiboscore）、无麻醉状态下的Schirmer I泪液试验（SIT）、角膜荧光素染色（CFS）、部分眨眼率（PBR）、脂质层厚度（LLT）、眼表疾病指数（OSDI）。对研究获得的结果在各分组之间进行分析和比较。
OSAS组的FNITBUT、MNITBUT和TMH较低。OSAS组的OSDI、CFS、Meiboscore和PBR高于对照组。轻度和中度以及重度OSAS亚组的TMH在统计学上显著低于对照组，OSDI和PBR高于对照组。同时，我们发现两个OSAS亚组之间没有显著差异。重度OSAS组的CFS高于轻度和中度OSAS组。重度OSAS亚组的FNITBUT、MNITBUT显著低于对照组，Meiboscore高于对照组，并且重度OSAS对象的MNITBUT高于轻度和中度OSAS对象。LLT和SIT在对照组和OSAS亚组之间没有表现出显著差异。FNITBUT和MNITBUT与BMI呈显著负相关，而Meiboscore与AHI呈显著正相关。
OSAS患者有干眼倾向，而对照组没有。这提示我们OSAS患者应更加关注眼表护理。
