Liang Shuang, Niu Wanxia, Wang Helei, Yang Lixia
Department of Pediatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
Department of Ophthalmology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
Diabetes Metab Syndr Obes. 2021 Aug 28;14:3787-3793. doi: 10.2147/DMSO.S323770. eCollection 2021.
The purpose of the study was to evaluate the changes in the ocular surface parameters of type 2 diabetic patients.
This study is a cross-sectional observational study. It included 76 eyes of 38 patients with type 2 diabetes and 183 eyes of 92 non-diabetic controls. The diabetic subjects were divided into two groups based on diabetic duration. Ocular surface parameters were assessed for all participants.
The diabetic group had a significantly thinner lipid layer thickness (LLT) (p = 0.008) than non-diabetic controls. LLT in the subgroup with diabetic duration ≥10 years was significantly thinner than that in the subgroup with diabetic duration <10 years (p = 0.006). Multivariate linear regression analysis showed that LLT was associated with the duration of diabetes (β = -1.497, p = 0.009) and Schirmer I test (SIT) score (β = 0.852, p = 0.04) in diabetic. Diabetic duration was significantly negatively associated with LLT (β = -0.062, p = 0.004) and significantly positively associated with ocular surface disease index (OSDI) (β = 0.087, p = 0.039).
Diabetic patients exhibit significantly reduced LLT and this trend becomes more pronounced with increased duration of diabetes.
本研究旨在评估2型糖尿病患者眼表参数的变化。
本研究为横断面观察性研究。纳入38例2型糖尿病患者的76只眼和92例非糖尿病对照者的183只眼。根据糖尿病病程将糖尿病受试者分为两组。对所有参与者进行眼表参数评估。
糖尿病组的脂质层厚度（LLT）显著低于非糖尿病对照组（p = 0.008）。糖尿病病程≥10年亚组的LLT显著低于糖尿病病程<10年亚组（p = 0.006）。多因素线性回归分析显示，糖尿病患者的LLT与糖尿病病程（β = -1.497，p = 0.009）和泪液分泌试验（SIT）评分（β = 0.852，p = 0.04）相关。糖尿病病程与LLT显著负相关（β = -0.062，p = 0.004），与眼表疾病指数（OSDI）显著正相关（β = 0.087，p = 0.039）。
糖尿病患者的LLT显著降低，且随着糖尿病病程的延长，这种趋势更加明显。
