Drayer J I, Hall W D, Smith V E, Weber M A, Wollam G L, White W B
Clin Pharmacol Ther. 1986 Dec;40(6):679-85. doi: 10.1038/clpt.1986.244.
Reductions in left ventricular (LV) mass have been reported after antihypertensive therapy with certain sympatholytic agents and converting enzyme inhibitors, but little or no improvement has been noted after vasodilator therapy. In this study we evaluated the effect of the calcium channel blocker nitrendipine on echocardiographic LV mass. During a 12-month period, nitrendipine was used as monotherapy in 30 patients and in combination with propranolol or a diuretic in an additional 28 patients. Nitrendipine monotherapy lowered supine blood pressure from 148/97 to 136/83 mm Hg, but LV mass did not change significantly. Supine blood pressure decreased from 155/103 to 134/86 mm Hg in patients receiving combination therapy but, again, changes in LV mass were not significant. These data suggest that nitrendipine is effective in lowering blood pressure, but this is not associated with a significant decrease in LV mass in patients with mild hypertension.
据报道，使用某些抗交感神经药和转换酶抑制剂进行抗高血压治疗后，左心室（LV）质量有所降低，但血管扩张剂治疗后几乎没有改善或未观察到改善。在本研究中，我们评估了钙通道阻滞剂尼群地平对超声心动图测量的左心室质量的影响。在12个月的时间里，30例患者单独使用尼群地平进行治疗，另外28例患者将尼群地平与普萘洛尔或利尿剂联合使用。单独使用尼群地平治疗可使仰卧位血压从148/97毫米汞柱降至136/83毫米汞柱，但左心室质量没有显著变化。接受联合治疗的患者仰卧位血压从155/103毫米汞柱降至134/86毫米汞柱，但左心室质量的变化同样不显著。这些数据表明尼群地平在降低血压方面有效，但对于轻度高血压患者，这与左心室质量的显著降低无关。
