Gosse P, Lacroix P, Roudaut R, Dallocchio M
Hôpital Cardiologique du Haut-Lévêque, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux-Pessac, France.
Cardiovasc Drugs Ther. 1989 Aug;3(4):525-8. doi: 10.1007/BF01865511.
Eighteen hypertensive patients (13 males, 5 females; age 48 +/- 13; diastolic blood pressure greater than 95 mmHg), either previously untreated or who had been off treatment for more than 3 months, underwent M-mode echocardiography before (DO) and after (D90) 3 months of nicardipine therapy (60-90 mg/day). All echocardiograms were read blind, and left ventricular mass (LVM) was calculated (Devereaux's formula). Blood pressure was significantly reduced after 3 months from 167 +/- 15/102 +/- 8 mmHg on DO to 152 +/- 16/92 +/- mmHg on D90 (p less than 0.001). The reduction in LVM was not significant: 266 +/- 95 g on DO, 247 +/- 78 g on D90. There was a trend to a higher (although nonsignificant) LVM reduction in patients with left ventricular hypertrophy at entry (-11%, n = 11) than in patients without left ventricular hypertrophy (-2%), n = 7).
18例高血压患者（男13例，女5例；年龄48±13岁；舒张压大于95mmHg），既往未接受治疗或已停药3个月以上，在尼卡地平治疗（60 - 90mg/天）前（DO）和3个月后（D90）接受了M型超声心动图检查。所有超声心动图均由专人在不知情的情况下解读，并计算左心室质量（LVM）（采用Devereaux公式）。3个月后血压显著降低，DO时为167±15/102±8mmHg，D90时为152±16/92±mmHg（p<0.001）。LVM的降低不显著：DO时为266±95g，D90时为247±78g。与无左心室肥厚的患者（n = 7，降低2%）相比，入组时存在左心室肥厚的患者（n = 11，降低11%）LVM降低幅度有更高（尽管不显著）的趋势。
