College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China.
Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China.
ACS Nano. 2023 Oct 24;17(20):20445-20461. doi: 10.1021/acsnano.3c06967. Epub 2023 Oct 6.
Radiotherapy is inevitably accompanied by some degree of radiation resistance, which leads to local recurrence and even therapeutic failure. To overcome this limitation, herein, we report the room-temperature synthesis of an iodine- and ferrocene-loaded covalent organic framework (COF) nanozyme, termed , for the enhancement of radiotherapeutic efficacy in the treatment of radioresistant esophageal cancer. The iodine atoms on the COF framework not only exerted a direct effect on radiotherapy, increasing its efficacy by increasing X-ray absorption, but also promoted the radiolysis of water, which increased the production of reactive oxygen species (ROS). In addition, the ferrocene surface decoration disrupted redox homeostasis by increasing the levels of hydroxyl and lipid peroxide radicals and depleting intracellular antioxidants. Both and experiments substantiated the excellent radiotherapeutic response of . This study demonstrates the potential of COF-based multinanozymes as radiosensitizers and suggests a possible treatment integration strategy for combination oncotherapy.
放射治疗不可避免地伴随着一定程度的辐射抗性，这导致局部复发甚至治疗失败。为了克服这一限制，在此，我们报告了一种碘和二茂铁负载的共价有机骨架（COF）纳米酶的室温合成，称为 ，用于增强放射性抵抗食管癌的放射治疗效果。COF 骨架上的碘原子不仅对放射治疗有直接影响，通过增加 X 射线吸收来提高其疗效，而且还促进水的辐射分解，增加活性氧（ROS）的产生。此外，二茂铁表面修饰通过增加羟基和脂质过氧自由基的水平以及耗尽细胞内抗氧化剂来破坏氧化还原平衡。和 实验都证实了 的优异放射治疗反应。这项研究证明了基于 COF 的多纳酶作为放射增敏剂的潜力，并为联合肿瘤治疗的治疗整合策略提供了一种可能。
