Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
School of Public Health, Zhejiang University, Hangzhou, China; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Diabetes Metab Syndr. 2023 Oct;17(10):102871. doi: 10.1016/j.dsx.2023.102871. Epub 2023 Sep 29.
To test the associations of sugar-sweetened beverage, artificially sweetened beverage, and pure fruit/vegetable juice consumption with visceral adipose tissue (VAT) mass at baseline and follow-up and to determine whether BMI and genetic risk of VAT mass modified the associations.
A total of 203,348 participants from UK Biobank with consumption data on three beverages were included. Participants were categorized into nonconsumers and consumers with >0-1, >1-2 and >2 L/week. A sex-specific prediction model was used to calculate VAT mass. A weighted genetic risk score for high VAT mass was calculated.
The participants with a sugar-sweetened beverage and artificially sweetened beverage consumption of >2 L/week had the greatest B values [B (95% CI): 24.02 (16.53, 31.51) and 60.81 (52.08, 69.54) in men, respectively; 10.20 (5.92, 14.48) and 24.72 (20.80, 28.64) in women]. Low and moderate intake of pure fruit/vegetable juices showed a significantly inverse association with VAT mass in men [-10.52 (-15.37, -5.67); -6.46 (-11.27, -1.65)] and women [-6.70 (-8.99, -4.41); -5.93 (-8.33, -3.54)]. Regarding changes in VAT mass, participants who consumed >2 L/week of sugar-sweetened beverages and artificially sweetened beverages had greater changes. BMI but not genetic risk modified the associations between beverage intake and VAT mass, which were strengthened in participants with BMI ≥25 kg/m for sugar-sweetened and artificially sweetened beverage consumption.
Higher consumption of sugar-sweetened beverages or artificially sweetened beverages was associated with greater VAT mass regardless of genetic risk. Mild-to-moderate intake of pure fruit/vegetable juices was linked to lower VAT mass.
检测含糖饮料、人工甜味饮料和纯果汁/蔬菜汁的摄入与基线和随访时内脏脂肪组织（VAT）质量的相关性，并确定 BMI 和 VAT 质量的遗传风险是否改变了这种相关性。
共纳入 UK Biobank 中 203348 名有三种饮料摄入数据的参与者。参与者分为非饮用者和饮用者，其中>0-1、>1-2 和>2L/周。采用特异性预测模型计算 VAT 质量。计算了高 VAT 质量的遗传风险评分。
每周饮用>2L 含糖饮料和人工甜味饮料的参与者，B 值最大[男性分别为 24.02（16.53，31.51）和 60.81（52.08，69.54）；女性分别为 10.20（5.92，14.48）和 24.72（20.80，28.64）]。男性和女性中，低、中度饮用纯果汁/蔬菜汁与 VAT 质量呈显著负相关[-10.52（-15.37，-5.67）；-6.46（-11.27，-1.65)]和[-6.70（-8.99，-4.41）；-5.93（-8.33，-3.54）]。关于 VAT 质量的变化，每周饮用>2L 含糖饮料和人工甜味饮料的参与者变化更大。BMI 而非遗传风险改变了饮料摄入与 VAT 质量之间的相关性，这种相关性在 BMI≥25kg/m 的参与者中因含糖和人工甜味饮料的摄入而增强。
无论遗传风险如何，高含糖饮料或人工甜味饮料的摄入与更大的 VAT 质量相关。低到中度摄入纯果汁/蔬菜汁与较低的 VAT 质量相关。
