Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Aliment Pharmacol Ther. 2022 Sep;56(6):1018-1029. doi: 10.1111/apt.17149. Epub 2022 Jul 18.
Inflammatory bowel diseases (IBD) have been related to high-sugar dietary patterns, but the associations of different types of beverages with IBD risk are largely unknown.
To examine any associations between intake of sugar-sweetened beverages, artificially sweetened beverages and natural juices and IBD risk METHODS: This cohort study included 121,490 participants in the UK Biobank who were free of IBD at recruitment. Intake of beverages was obtained from repeated 24-h diet recalls in 2009-2012. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of beverage intake with IBD risk.
During a mean (standard deviation) follow-up of 10.2 (1.5) years, we documented 510 incident IBD cases, (143 Crohn's disease (CD) and 367 ulcerative colitis (UC)). Compared to non-consumers, participants consuming >1 unit per day of sugar-sweetened beverages were at significantly higher risk of IBD (HR 1.51, 95% CI 1.11-2.05), but the trend was non-significant (p-trend = 0.170). This association was significant for CD (HR 2.05, 95% CI 1.22-3.46), but not for UC (HR 1.31, 95% CI 0.89-1.92). We did not observe significant associations for the consumption of artificially sweetened beverages or natural juices.
Our findings suggest an association between consumption of sugar-sweetened beverages, rather than artificially sweetened beverages or natural juices, and IBD risk.
炎症性肠病（IBD）与高糖饮食模式有关，但不同类型饮料与 IBD 风险之间的关联在很大程度上尚不清楚。
研究摄入含糖饮料、人工甜味饮料和天然果汁与 IBD 风险之间的任何关联。
这项队列研究纳入了英国生物银行的 121490 名参与者，他们在招募时无 IBD。在 2009-2012 年期间通过多次 24 小时饮食回忆来获取饮料摄入量。使用 Cox 比例风险模型来估计饮料摄入与 IBD 风险之间的关联的风险比（HR）和 95%置信区间（CI）。
在平均（标准差）随访 10.2（1.5）年后，我们记录了 510 例新发 IBD 病例，（143 例克罗恩病（CD）和 367 例溃疡性结肠炎（UC））。与非消费者相比，每天饮用>1 份含糖饮料的参与者患 IBD 的风险显著升高（HR 1.51，95%CI 1.11-2.05），但趋势无统计学意义（p 趋势=0.170）。这种关联在 CD 中显著（HR 2.05，95%CI 1.22-3.46），但在 UC 中不显著（HR 1.31，95%CI 0.89-1.92）。我们没有观察到人工甜味饮料或天然果汁消费与 IBD 风险之间存在显著关联。
我们的研究结果表明，摄入含糖饮料而不是人工甜味饮料或天然果汁与 IBD 风险之间存在关联。
