Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China.
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China; Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, School of Stomatology, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou, Zhejiang 310006, China.
Int J Biol Macromol. 2023 Dec 31;253(Pt 5):127190. doi: 10.1016/j.ijbiomac.2023.127190. Epub 2023 Oct 5.
Bacterial biofilm formation and drug resistance are common issues associated with wound healing. Antimicrobial peptides (AMPs) are a new class of antimicrobial agents with the potential to solve these global health issues. New injectable adhesive antibacterial hydrogels have excellent prospects of becoming the next innovative wound-healing dressings. In this study, the hyaluronic acid was connected to the antibacterial peptide Plantaricin 149 (Pln149), obtaining HAD@AMP. HAD@AMP performed well in efficient antimicrobial activity, good histocompatibility, low drug resistance, low bacterial biofilm formation, and fast wound healing process which are essential for rapid healing of infected wound. During the hydrogel degradation process, Pln149 was released to inhibit bacterial communication and reduce bacterial biofilm formation. Meanwhile, HAD@AMP could up-regulate anti-inflammatory and pro-angiogenic factors, and down-regulate inflammatory factors to promote the healing of infected wounds, which provide a new idea for skin healing strategies.
细菌生物膜的形成和耐药性是与伤口愈合相关的常见问题。抗菌肽（AMPs）是一类新型的抗菌药物，具有解决这些全球健康问题的潜力。新型可注射的黏附性抗菌水凝胶有望成为下一代创新的伤口愈合敷料。在这项研究中，透明质酸与抗菌肽 Plantaricin 149（Pln149）连接，得到 HAD@AMP。HAD@AMP 在高效抗菌活性、良好的组织相容性、低耐药性、低细菌生物膜形成和快速伤口愈合过程方面表现出色，这对感染性伤口的快速愈合至关重要。在水凝胶降解过程中，Pln149 被释放出来抑制细菌通讯并减少细菌生物膜的形成。同时，HAD@AMP 可以上调抗炎和促血管生成因子，下调炎症因子，促进感染性伤口的愈合，为皮肤愈合策略提供了新的思路。
