School of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, PR China.
School of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, PR China.
Int J Biol Macromol. 2022 Jun 15;210:218-232. doi: 10.1016/j.ijbiomac.2022.05.024. Epub 2022 May 7.
Infected wound healing has always been a challenge in clinic. Effective and economic wound dressings with combined antibacterial activity and pro-healing function are highly desirable, especially in the context of infected wounds. An obvious advantage of antibacterial wound dressing is to avoid the overuse of antibiotics and the occurrence of drug resistance. Herein, an injectable hyaluronic acid hydrogel with antioxidative and photothermal antibacterial activity as a functional dressing was prepared, characterized and evaluated in an experimental infected wound model. This hydrogel was developed by loading graphene oxide (GO) in a natural polymer network consisting of hyaluronic acid grafted with tyramine (HT) and gelatin grafted with gallic acid (GGA). The HT/GGA/GO hydrogels have a porous cross-linked network structure and demonstrate a good stability, biocompatibility, antioxidant, hemostatic and photothermal antibacterial activity against Escherichia coli and Staphylococcus aureus. In addition, in vivo studies have shown that HT/GGA/GO hydrogel dressing combined with photothermal therapy can effectively prevent early infection and accelerate wound healing. These results indicated this functionalized injectable hydrogel HT/GGA/GO has a great potential in wound dressing application.
感染性伤口的愈合一直是临床治疗的难题。具有抗菌活性和促愈功能的有效且经济的伤口敷料是非常需要的，尤其是在感染性伤口的情况下。抗菌伤口敷料的一个明显优势是避免抗生素的过度使用和耐药性的发生。本文制备了一种具有抗氧化和光热抗菌活性的可注射透明质酸水凝胶，作为一种功能性敷料，在感染性伤口模型中进行了表征和评估。该水凝胶是通过将氧化石墨烯（GO）负载到由接枝有酪氨酸（HT）的透明质酸和接枝有没食子酸（GGA）的明胶组成的天然聚合物网络中而开发的。HT/GGA/GO 水凝胶具有多孔交联网络结构，表现出良好的稳定性、生物相容性、抗氧化、止血和对大肠杆菌和金黄色葡萄球菌的光热抗菌活性。此外，体内研究表明，HT/GGA/GO 水凝胶敷料结合光热疗法可以有效预防早期感染并加速伤口愈合。这些结果表明，这种功能化的可注射水凝胶 HT/GGA/GO 在伤口敷料应用方面具有很大的潜力。
