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两剂曲普利啶治疗变应性鼻炎。

Two doses of triprolidine for treatment of allergic rhinitis.

作者信息

Britton M G, Empey D W, John G C, Hodder M, Hughes D T

出版信息

Ann Allergy. 1979 May;42(5):330-2.

PMID:378040
Abstract

Two doses of triprolidine (2.5 mg t.i.d. and 1.25 mg t.i.d.) were compared with placebo in 32 patients suffering from allergic rhinitis. Triprolidine 2.5 mg t.i.d. was statistically significantly better than placebo (p less than 0.05) in reducing the symptoms of sneezing and eye irritation. Neither dose of triprolidine produced significant drowsiness during the second week of treatment.

摘要

在32例过敏性鼻炎患者中,将两剂曲普利啶(每日三次,每次2.5毫克和每日三次,每次1.25毫克)与安慰剂进行了比较。每日三次服用2.5毫克曲普利啶在减轻打喷嚏和眼部刺激症状方面在统计学上显著优于安慰剂(p小于0.05)。在治疗的第二周,两种剂量的曲普利啶均未产生明显的嗜睡症状。

相似文献

1
Two doses of triprolidine for treatment of allergic rhinitis.两剂曲普利啶治疗变应性鼻炎。
Ann Allergy. 1979 May;42(5):330-2.
2
A Double-blind crossover trial of pseudoephedrine and triprolidine, alone and in combination, for the treatment of allergenic rhinitis.
Ann Allergy. 1975 Jan;34(1):41-6.
3
[Double blind crossover study of pseudoephedrine and triprolidine alone and in combination in the treatment of allergic rhinitis (author's transl)].伪麻黄碱与曲普利啶单独及联合治疗变应性鼻炎的双盲交叉研究(作者译)
Prensa Med Mex. 1975 Nov-Dec;40(11-12):383-8.
4
An evaluation of triprolidine and pseudoephedrine in the treatment of allergic rhinitis.
Ann Allergy. 1981 Aug;47(2):87-91.
5
Prolonged treatment with acrivastine for seasonal allergic rhinitis.阿伐斯汀用于季节性变应性鼻炎的长期治疗。
J Int Med Res. 1989;17 Suppl 2:40B-46B.
6
French multicentre double-blind study to evaluate the efficacy and safety of acrivastine as compared with terfenadine in seasonal allergic rhinitis.一项法国多中心双盲研究,旨在评估阿伐斯汀与特非那定相比在季节性变应性鼻炎中的疗效和安全性。
J Int Med Res. 1989;17 Suppl 2:47B-53B.
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Acrivastine in two doses compared with placebo in a multicentre, parallel group study for the treatment of seasonal allergic rhinitis.在一项多中心平行组研究中,将阿伐斯汀分两次给药与安慰剂进行比较,用于治疗季节性变应性鼻炎。
Br J Clin Pract. 1989 Jan;43(1):11-4.
8
A cross-over comparison of acrivastine, pseudoephedrine and their combination in seasonal allergic rhinitis.阿伐斯汀、伪麻黄碱及其组合用于季节性变应性鼻炎的交叉对照比较。
Rhinology. 1990 Mar;28(1):33-40.
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J Int Med Res. 1989;17 Suppl 2:54B-68B.
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[A double-blind, placebo-controlled study on the efficacy of Rinasek in symptomatic treatment of seasonal and non-seasonal rhinitis].[一项关于利纳塞克对季节性和非季节性鼻炎症状性治疗疗效的双盲、安慰剂对照研究]
Med Pregl. 1995;48(7-8):255-9.

引用本文的文献

1
The effect of orally administered triprolidine and pseudoephedrine singly and combined on histamine-induced skin reactions.口服曲普利啶和伪麻黄碱单独及联合使用对组胺诱导的皮肤反应的影响。
Eur J Clin Pharmacol. 1982;22(5):411-2. doi: 10.1007/BF00542544.
2
A comparison of triprolidine and cyclizine on histamine (H1) antagonism, subjective effects and performance tests in man.曲普利啶与赛克利嗪对人体组胺(H1)拮抗作用、主观效应及性能测试的比较。
Br J Clin Pharmacol. 1982 Mar;13(3):441-4. doi: 10.1111/j.1365-2125.1982.tb01399.x.