Gibson J R, Medder K T, McDonnell K A, Bye C E, Hughes D T
Eur J Clin Pharmacol. 1982;22(5):411-2. doi: 10.1007/BF00542544.
The effect of a single oral dose of triprolidine and pseudoephedrine, singly and combined, on histamine-induced wheal and flare reactions, was assessed in a fully randomised, placebo-controlled, double-blind crossover study. Triprolidine alone and the combination had a significantly greater effect of (p less than 0.05) in reducing skin reactions than pseudoephedrine alone or placebo, but there was no significant difference between triprolidine ane the combination (p less than 0.05).
在一项完全随机、安慰剂对照、双盲交叉研究中，评估了单次口服曲普利啶和伪麻黄碱单独及联合使用对组胺诱导的风团和潮红反应的影响。单独使用曲普利啶和联合使用时，在减轻皮肤反应方面的效果（p小于0.05）显著大于单独使用伪麻黄碱或安慰剂，但曲普利啶与联合使用组之间无显著差异（p小于0.05）。
