Department of Ultrasound Imaging, The Affiliated Hospital of Southwest Medical University, Sichuan, China.
Department of Ultrasound Imaging, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Sichuan, China.
J Coll Physicians Surg Pak. 2023 Oct;33(10):1100-1105. doi: 10.29271/jcpsp.2023.10.1100.
To investigate the predictive value of the carotid plaque contrast-enhanced ultrasound (CEUS) score and blood homocysteine (HCY) in senile metabolic syndrome (MetS) complicated by cerebral infarction.
Observational study. Place and Duration of the Study: Department of Ultrasound Imaging, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, China, from July 2020 to December 2021.
A total of 118 senile MetS patients complicated by cerebral infarction were selected as Group A, and 103 senile MetS patients without cerebral infarction were selected as Group B. Both groups were compared in terms of cardiovascular risk factors and ultrasonic examination of carotid plaques. The independent risk factors for cerebral infarction among senile MetS patients were analysed using logistic regression. An ROC curve was used to assess the predictive value of statistically significant risk factors in senile MetS complicated by cerebral infarction.
Significant differences were observed in smoking, abdominal circumference, blood pressure, HCY, fasting blood glucose, high-density and low-density lipoprotein cholesterol, triacylglycerol, carotid plaque thickness, CEUS score, lumen stenosis, and ulcer plaque between the two groups. Logistic regression analysis showed that the plaque CEUS score and HCY were independent risk factors for senile MetS complicated by cerebral infarction. The areas under the ROC curve for the CEUS score and HCY were 0.795 and 0.812, respectively, and was 0.858 for the combined diagnosis of both. When the CEUS score was ≥2 and HCY was ≥16.45 mmol/l, the sensitivity and specificity of predicted senile MetS complicated by cerebral infarction were 83.1% and 74.8%, respectively.
The carotid plaque CEUS score and blood HCY exhibit a substantial predictive capacity for cerebral infarction in elderly MetS patients. The combined diagnostic efficacy of the two is superior.
Contrast-enhanced ultrasound, Homocysteine, Elderly, Metabolic syndrome, Cerebral infarction, Carotid plaque.
探讨颈动脉斑块超声造影（CEUS）评分和血液同型半胱氨酸（HCY）对老年代谢综合征（MetS）合并脑梗死的预测价值。
观察性研究。地点和时间：中国西南医科大学附属中医院超声影像科，2020 年 7 月至 2021 年 12 月。
选取老年 MetS 合并脑梗死患者 118 例作为 A 组，老年 MetS 无脑梗死患者 103 例作为 B 组。比较两组患者的心血管危险因素和颈动脉斑块超声检查情况。采用 Logistic 回归分析老年 MetS 患者脑梗死的独立危险因素。采用 ROC 曲线评估有统计学意义的危险因素对老年 MetS 合并脑梗死的预测价值。
两组患者在吸烟、腹围、血压、HCY、空腹血糖、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、三酰甘油、颈动脉斑块厚度、CEUS 评分、管腔狭窄、溃疡斑块等方面存在显著差异。Logistic 回归分析显示，斑块 CEUS 评分和 HCY 是老年 MetS 合并脑梗死的独立危险因素。CEUS 评分和 HCY 的 ROC 曲线下面积分别为 0.795 和 0.812，联合诊断的曲线下面积为 0.858。当 CEUS 评分≥2 分且 HCY≥16.45mmol/L 时，预测老年 MetS 合并脑梗死的敏感性和特异性分别为 83.1%和 74.8%。
颈动脉斑块 CEUS 评分和血液 HCY 对老年 MetS 患者脑梗死具有较强的预测能力，两者联合诊断的效果优于单项检测。
超声造影；同型半胱氨酸；老年人；代谢综合征；脑梗死；颈动脉斑块。
