调控上皮-间充质转化的机械转导通路。
Mechanotransduction pathways in regulating epithelial-mesenchymal plasticity.
机构信息
Department of Pharmacology, Moores Cancer Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.
Department of Pharmacology, Moores Cancer Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA; Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.
出版信息
Curr Opin Cell Biol. 2023 Dec;85:102245. doi: 10.1016/j.ceb.2023.102245. Epub 2023 Oct 5.
The extracellular matrix (ECM) provides structural support for cells and mediates cell-stromal communications. In addition to ECM proteins, mechanical force exerted from the ECM serves as a critical regulator of many biological processes. Epithelial-mesenchymal transition (EMT) is a cellular process by which epithelial cells loosen their cellular junctions and migrate and invade in a more mesenchymal fashion. Recent studies show that increasing ECM stiffness can impinge on cellular signaling pathways through mechanotransduction to promote carcinoma cells to undergo EMT, suggesting that mechanical force exerted by the ECM plays a critical role in tumor invasion and metastasis. Here, we highlight recent work utilizing innovative approaches to study mechanotransduction and summarize newly discovered mechanisms by which mechanosensors and responders regulate EMT during tumor progression and metastasis.
细胞外基质 (ECM) 为细胞提供结构支持，并介导细胞-基质通讯。除了 ECM 蛋白，ECM 产生的机械力也是许多生物学过程的关键调节因子。上皮-间充质转化 (EMT) 是一种细胞过程，在此过程中，上皮细胞松开细胞连接，并以更间充质的方式迁移和侵袭。最近的研究表明，增加 ECM 硬度可以通过机械转导影响细胞信号通路，促进癌细胞发生 EMT，这表明 ECM 产生的机械力在肿瘤侵袭和转移中起着关键作用。在这里，我们重点介绍了利用创新方法研究机械转导的最新工作，并总结了机械感受器和响应物在肿瘤进展和转移过程中调节 EMT 的新发现机制。
Zotero 插件