Department of Obstetrics and Gynaecology, National University Hospital, 5 Lower Kent Ridge Road, Level 3, 119074, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 12, 119228, Singapore.
Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 12, 119228, Singapore.
Maturitas. 2023 Dec;178:107853. doi: 10.1016/j.maturitas.2023.107853. Epub 2023 Oct 6.
Menopausal symptoms can substantially impact quality of life. We studied somatic, psychological, and urogenital symptoms and their associated factors.
Cross-sectional study of healthy midlife Singaporean women from three major Asian ethnic groups.
In 2014-16, women aged 45 to 69 attending well-woman clinics at the National University Hospital Singapore completed the Menopause Rating Scale (MRS). Sociodemographic, reproductive, medical, anthropometric, body composition, and physical performance characteristics were assessed using validated questionnaires and strict protocols. We analysed sub-scales and total scores by median split, and adjusted odds ratios using multivariable logistic regression.
Of the 1054 eligible women, 62.6 % reported at least one moderate to extremely severe symptom. The top five menopausal symptoms were joint and muscle discomfort, sleep problems, vaginal dryness, physical and mental exhaustion, and hot flushes. Higher total scores on the MRS were associated with moderate disability (adjusted odds ratio: 9.80, 95 % confidence interval: 2.88-33.34), poorer self-rated health status (2.18, 1.60-2.97), menstrual irregularity at 25 years (1.63, 1.07-2.49), and slower chair stands (1.49, 1.09-2.03). Age ≥65 (0.54, 0.30-0.94) and a lower level of education (0.45, 0.26-0.76) had significant inverse associations with total MRS score.
Menopausal symptoms were associated with disability, poorer health status, and weaker lower-body muscle strength. These data add to the limited Asian evidence and raise the profile of this important area of health.
更年期症状会极大地影响生活质量。我们研究了躯体、心理和泌尿生殖系统症状及其相关因素。
对来自三个主要亚洲种族的新加坡中年健康女性进行的横断面研究。
2014-16 年，在新加坡国立大学医院参加妇女健康诊所的 45 至 69 岁女性完成了更年期评定量表（MRS）。使用经过验证的问卷和严格的方案评估了社会人口统计学、生殖、医学、人体测量学、身体成分和身体表现特征。我们按中位数分割分析了子量表和总评分，并使用多变量逻辑回归分析了调整后的优势比。
在 1054 名合格女性中，62.6%报告至少有一种中度至极度严重的症状。更年期的前五大症状是关节和肌肉不适、睡眠问题、阴道干燥、身心疲惫和热潮红。MRS 总评分较高与中度残疾相关（调整后的优势比：9.80，95%置信区间：2.88-33.34），自我报告的健康状况较差（2.18，1.60-2.97），25 岁时月经不规则（1.63，1.07-2.49），以及椅子站立速度较慢（1.49，1.09-2.03）。年龄≥65 岁（0.54，0.30-0.94）和教育程度较低（0.45，0.26-0.76）与总 MRS 评分呈显著负相关。
更年期症状与残疾、较差的健康状况和较弱的下肢肌肉力量有关。这些数据增加了亚洲有限的证据，并提高了这一重要健康领域的知名度。
