Dundee J W, Halliday N J, McMurray T J
Eur J Anaesthesiol. 1986 May;3(3):247-51.
The effects of pretreatment with aspirin and probenecid, two drugs which are highly bound to albumin, on an induction dose of thiopentone and time to onset of action of a fixed dose of midazolam were investigated. Both drugs significantly potentiate thiopentone and shorten the induction time with midazolam. The importance of individual variations in plasma proteins in influencing the action of highly bound drugs is stressed.
研究了预先使用阿司匹林和丙磺舒（两种与白蛋白高度结合的药物）对硫喷妥钠诱导剂量及固定剂量咪达唑仑起效时间的影响。两种药物均显著增强硫喷妥钠的作用，并缩短咪达唑仑的诱导时间。强调了血浆蛋白个体差异对高度结合药物作用的影响。
