Halliday N J, Dundee J W, Collier P S, Loughran P G, Harper K W
Anaesthesia. 1985 Aug;40(8):763-6. doi: 10.1111/j.1365-2044.1985.tb11001.x.
The action of midazolam is influenced by serum protein binding as seen in the relationship between the time of onset of action of a fixed dose of the drug and the plasma albumin. Pretreatment with intravenous aspirin produces a decrease in the in vitro binding of midazolam. In vivo this is manifest as an increase in the rapidity of action of the benzodiazepines. Probenecid pretreatment will also cause a decrease in the onset time of midazolam. However, this is not due to altered plasma protein binding of the sedative.
咪达唑仑的作用受血清蛋白结合的影响，这在固定剂量药物的起效时间与血浆白蛋白之间的关系中可见。静脉注射阿司匹林预处理会使咪达唑仑的体外结合减少。在体内，这表现为苯二氮䓬类药物起效速度加快。丙磺舒预处理也会使咪达唑仑的起效时间缩短。然而，这并非由于镇静剂的血浆蛋白结合改变所致。
