Woo Stone, Landwehr Eleanor M, Shenvi Ryan A
Department of Chemistry, Scripps Research, La Jolla, California 92037, United States.
Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research, La Jolla, California 92037, United States.
Tetrahedron. 2022 Nov 5;126. doi: 10.1016/j.tet.2022.133064. Epub 2022 Oct 5.
Efficient syntheses of valuable natural products open gateways from kind learning environments to wicked worlds, where long-term, interdisciplinary research questions can be asked and answered. In this Perspective, we discuss the (GB) alkaloids, metabolites of a rainforest canopy tree that exhibit potent but poorly understood effects in humans, including accounts of hallucination. Recent syntheses from our group have opened up GB alkaloid chemical space for investigation by way of new cross-coupling reactions and gram-scale target production. Although natural product synthesis can be challenging, its objective is obvious. Realization of long-term, enabling goals will be a circuitous journey at the interface of chemistry, pharmacology and neuroscience-a potent mix to foster discovery in the coming century.
高效合成有价值的天然产物为从良性学习环境通向恶劣世界打开了大门，在这个恶劣世界中，可以提出并回答长期的跨学科研究问题。在这篇观点文章中，我们讨论了（GB）生物碱，它是一种雨林冠层树木的代谢产物，在人体中表现出强大但尚未完全了解的作用，包括幻觉现象。我们团队最近的合成工作通过新的交叉偶联反应和克级目标产物的制备，开辟了GB生物碱化学空间以供研究。尽管天然产物合成可能具有挑战性，但其目标是明确的。实现长期的、具有推动作用的目标将是一段在化学、药理学和神经科学交叉领域的迂回旅程——这是在即将到来的世纪中促进发现的有力组合。
