An Haoyu, Xue Qiyun, Zhang Jingyi
School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China.
Faculty of Science, The University of Hong Kong, Hong Kong SAR, China.
Front Neurol. 2023 Sep 21;14:1225403. doi: 10.3389/fneur.2023.1225403. eCollection 2023.
The present study aimed to explore the correlation of serum total folic acid concentration with severe difficulty falling asleep among US adults.
Cross-sectional data were collected from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2006 and 2007 to 2008 cycles. Participants were divided into the severe difficulty falling asleep (SDFA) group and the control group according to the monthly frequency of having difficulty falling asleep. Serum total folic acid was taken as independent and dependent variables, respectively. The correlation of serum total folic acid concentration with severe difficulty falling asleep was examined using multivariable logistic regression models, where the adjusted odds ratio (OR) and 95% confidential intervals (CIs) were calculated.
Overall, 8,926 individuals from the NHANES 2005 to 2006 and 2007 to 2008 waves were included in the analysis, of whom 683 participants had severe difficulty falling asleep. Higher serum total folic acid concentration (ng/ml) was associated with lower odds of severe difficulty falling asleep after adjusting for potentially confounding factors (OR = 0.98; 95% CI: 0.97-1.00), while participants at the highest quartile had the least odds of severe difficulty falling asleep (OR = 0.55; 95% CI: 0.40-0.74). The subgroup analysis based on gender, smoking history, and diabetes showed that this negative correlation was more significant in males, smokers, and nondiabetic population after adjusting for confounding factors.
High levels of serum folic acid were significantly related to less odds of severe difficulty in falling asleep among US adults, suggesting that folic acid supplementation may be beneficial to the prevention and even treatment of severe difficulty falling asleep.
本研究旨在探讨美国成年人血清总叶酸浓度与严重入睡困难之间的相关性。
收集2005年至2006年以及2007年至2008年期间美国国家健康与营养检查调查（NHANES）的横断面数据。根据每月入睡困难的频率，将参与者分为严重入睡困难（SDFA）组和对照组。血清总叶酸分别作为自变量和因变量。使用多变量逻辑回归模型检验血清总叶酸浓度与严重入睡困难之间的相关性，并计算调整后的优势比（OR）和95%置信区间（CI）。
总体而言，分析纳入了来自2005年至2006年以及2007年至2008年NHANES调查的8926名个体，其中683名参与者存在严重入睡困难。在调整潜在混杂因素后，较高的血清总叶酸浓度（ng/ml）与严重入睡困难的较低几率相关（OR = 0.98；95% CI：0.97 - 1.00），而处于最高四分位数的参与者出现严重入睡困难的几率最低（OR = 0.55；95% CI：0.40 - 0.74）。基于性别、吸烟史和糖尿病的亚组分析表明，在调整混杂因素后，这种负相关在男性、吸烟者和非糖尿病人群中更为显著。
在美国成年人中，高水平的血清叶酸与严重入睡困难几率较低显著相关，这表明补充叶酸可能有助于预防甚至治疗严重入睡困难。
