Suliman Aasir M, Alamin Mohammed A, Ul Haq Irfan
Pulmonology, Hamad Medical Corporation, Doha, QAT.
Internal Medicine, Hamad Medical Corporation, Doha, QAT.
Cureus. 2023 Sep 5;15(9):e44730. doi: 10.7759/cureus.44730. eCollection 2023 Sep.
Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infection (UTI) treatment and prophylaxis. Although relatively rare, nitrofurantoin can cause a spectrum of lung injuries, from acute hypersensitivity reactions that might be fatal to chronic reactions involving fibrosis. Therefore, treating physicians' awareness and regular monitoring is essential for early recognition, drug withdrawal, avoiding unnecessary treatment, and preventing irreversible fibrosis. Here, we report the case of a 77-year-old woman who had been hospitalized with interstitial lung disease due to chronic nitrofurantoin therapy. Despite the severity of symptoms and the extent of radiological lung involvement, she returned to her clinical and radiological baseline shortly following the drug cessation.
呋喃妥因是一种常用于治疗和预防尿路感染（UTI）的抗生素。虽然相对罕见，但呋喃妥因可导致一系列肺部损伤，从可能致命的急性超敏反应到涉及纤维化的慢性反应。因此，治疗医生的意识和定期监测对于早期识别、停药、避免不必要的治疗以及预防不可逆的纤维化至关重要。在此，我们报告一例77岁女性因慢性呋喃妥因治疗导致间质性肺病住院的病例。尽管症状严重且肺部影像学受累范围广泛，但在停药后不久她就恢复到了临床和影像学基线状态。
