Nabuurs M J, van der Molen E J
Zentralbl Veterinarmed A. 1989 Mar;36(3):209-17. doi: 10.1111/j.1439-0442.1989.tb00721.x.
An experiment was designed to study the clinical effects of carbadox in pigs. Five different carbadox levels were tested namely 25, 50, 100, 150, and 200 ppm. They were compared with a control group fed on a diet without medication. After 10 weeks all pigs received a diet without carbadox till the end of the experiment, 21 weeks after the start. After two weeks of carbadox treatment the first clinical signs were observed in the 200 ppm group. The most obvious effects seen were production of dry faeces and drinking of urine from the floor or from pen-mates. Other signs were a decreased abdominal volume, a pale skin with long withered hair, perverted eating and a restless behaviour. The haematocrit values in pigs receiving 100 ppm and upwards were increased. There was a negative correlation between the dose of carbadox and the time after which the response occurred. Weight gain was significantly lowered and feed conversion essentially poorer in the 200 ppm, 150 ppm and 100 ppm groups during the treatment as compared to the controls. No growth promoting effect was seen in the 25 and 50 ppm groups. After withdrawal of carbadox, clinical signs persisted in the 150 and 200 ppm groups. The 100 ppm group produced normal faeces 5 weeks after withdrawal, whereas drinking of urine persisted. From this study it appears that only an oral dosage of 25 ppm or lower can be given to pigs without risks of toxic effects. The widely claimed growth promoting effect of carbadox could not be confirmed in this study. This might be due to the small number of animals per group.
设计了一项实验来研究卡巴多司对猪的临床效果。测试了五个不同的卡巴多司水平，即25、50、100、150和200 ppm。将它们与喂食无药物日粮的对照组进行比较。10周后，所有猪都改为喂食不含卡巴多司的日粮，直至实验结束，即开始后的21周。在卡巴多司处理两周后，在200 ppm组中观察到了最初的临床症状。最明显的症状是粪便干结以及从地面或同栏伙伴身上舔尿。其他症状包括腹围减小、皮肤苍白且毛发干枯、饮食异常和行为不安。接受100 ppm及以上剂量的猪的血细胞比容值升高。卡巴多司剂量与出现反应的时间之间呈负相关。与对照组相比，在治疗期间，200 ppm、150 ppm和100 ppm组的体重增加显著降低，饲料转化率也明显较差。25 ppm和50 ppm组未观察到生长促进作用。停用卡巴多司后，150 ppm和200 ppm组的临床症状仍然存在。100 ppm组在停药5周后粪便恢复正常，但舔尿行为仍然存在。从这项研究看来，给猪口服25 ppm或更低剂量的卡巴多司才不会有中毒风险。本研究无法证实卡巴多司广泛宣称的生长促进作用。这可能是由于每组动物数量较少。
