大鼠肝脏鸟氨酸转氨甲酰酶的周转率
Turnover of rat liver ornithine transcarbamylase.
作者信息
Wallace R, Knecht E, Grisolía S
出版信息
FEBS Lett. 1986 Nov 24;208(2):427-30. doi: 10.1016/0014-5793(86)81062-6.
PMID:3780979
Abstract
The relative half-life of ornithine transcarbamylase from rat liver has been determined using the double isotope technique and affinity chromatography. The calculated half-life (6-9 days) is similar to that of mitochondria and of the other mitochondrial enzyme of the urea cycle, carbamoyl-phosphate synthase. Therefore, both mitochondrial urea cycle enzymes are most probably degraded mainly via the lysosomal (autophagic) pathway of mitochondrial protein degradation.
摘要
利用双同位素技术和亲和色谱法测定了大鼠肝脏中鸟氨酸转氨甲酰酶的相对半衰期。计算得出的半衰期（6 - 9天）与线粒体以及尿素循环中的另一种线粒体酶——氨甲酰磷酸合酶的半衰期相似。因此，这两种线粒体尿素循环酶很可能主要通过线粒体蛋白质降解的溶酶体（自噬）途径被降解。
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