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StuA 转录因子与 pH 响应调控因子 PacC 相互作用，共同参与了宿主选择性毒素和柑橘致病力的生物合成。

The StuA transcription factor interacting with the pH-responsive regulator PacC for the biosynthesis of host-selective toxin and virulence in citrus.

机构信息

The Key Laboratory of Molecular Biology of Crop Pathogens and Insects of Ministry of Agriculture, The Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Institute of Biotechnology, Zhejiang University , Hangzhou, China.

Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang Province, College of Horticulture Science, Zhejiang Agriculture & Forestry University , Hangzhou, China.

出版信息

Microbiol Spectr. 2023 Dec 12;11(6):e0233523. doi: 10.1128/spectrum.02335-23. Epub 2023 Oct 9.

DOI:10.1128/spectrum.02335-23
PMID:37812002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10715145/
Abstract

In this study, we used as a biological model to report the role of StuA in phytopathogenic fungi. Our findings indicated that StuA is required for toxin (ACT) biosynthesis and fungal virulence. In addition, StuA physically interacts with PacC. Disruption of or led to decreased expression of seven toxin biosynthetic genes (ACCT) and toxin production. PacC could recognize and bind to the promoter regions of and . Our results revealed a previously unrecognized (StuA-PacC)→ACTTR module for the biosynthesis of ACT in , which also provides a framework for the study of StuA in other fungi.

摘要

在本研究中，我们以 为生物模型，报道了 StuA 在植物病原真菌中的作用。研究结果表明，StuA 是毒素（ACT）生物合成和真菌毒力所必需的。此外，StuA 与 PacC 发生物理相互作用。破坏 或 导致七个毒素生物合成基因（ACCT）和毒素产生的表达下降。PacC 可以识别并结合 和 的启动子区域。我们的结果揭示了一个以前未被识别的（StuA-PacC）→ACTTR 模块，用于 ACT 在 中的生物合成，这也为在其他真菌中研究 StuA 提供了一个框架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/800283e2e27c/spectrum.02335-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/a601417dec13/spectrum.02335-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/98d55bcf08a0/spectrum.02335-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/c90a9bd7a380/spectrum.02335-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/7a88b7191e6f/spectrum.02335-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/35e47bb00086/spectrum.02335-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/800283e2e27c/spectrum.02335-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/a601417dec13/spectrum.02335-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/98d55bcf08a0/spectrum.02335-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/c90a9bd7a380/spectrum.02335-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/7a88b7191e6f/spectrum.02335-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/35e47bb00086/spectrum.02335-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06a/10715145/800283e2e27c/spectrum.02335-23.f006.jpg

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