N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Pr. 47, 119334 Moscow, Russian Federation.
Department of Chemistry, Perm State University, Bukireva St. 15, 614990 Perm, Russian Federation.
Org Biomol Chem. 2023 Oct 25;21(41):8215-8243. doi: 10.1039/d3ob01141k.
Epoxyquinoids are of continuing interest due to their wide natural distribution and diverse biological activities, including, but not limited to, antibacterial, antifungal, anticancer, enzyme inhibitory, and others. The last review on their total synthesis was published in 2017. Since then, almost 100 articles have been published on their isolation from nature and their biological profile. In addition, the review specifically considers synthesis, including total and enantioselective, as well as the development of shorter approaches for the construction of epoxyquinoids with complex chemical architecture. Thus, this review focuses on progress in this area in order to stimulate further research.
由于环氧喹啉类化合物广泛存在于自然界中，具有多种生物活性，包括但不限于抗菌、抗真菌、抗癌、抑制酶等，因此它们一直受到关注。上一次关于它们的全合成综述发表于 2017 年。自那时以来，已有近 100 篇文章报道了它们在自然界中的分离及其生物特征。此外，该综述特别考虑了合成，包括全合成和对映选择性合成，以及开发用于构建具有复杂化学结构的环氧喹啉类化合物的更短方法。因此，本综述重点介绍了该领域的进展，以激发进一步的研究。
