Universidade Federal da Bahia (UFBA/EBSERH), Hospital Universitário Professor Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil.
Universidade Federal da Bahia (UFBA/EBSERH), Hospital Universitário Professor Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil; Fundação Bahiana de Infectologia, Salvador, BA, Brazil.
Braz J Infect Dis. 2023 Sep-Oct;27(5):102811. doi: 10.1016/j.bjid.2023.102811. Epub 2023 Oct 6.
COVID-19 can trigger different clinical presentations in distinct population groups, some of which are considered at higher risk of SARS-CoV-2 infection. Little is known about the susceptibility of certain populations to the infection.
We aimed to determine the prevalence of COVID-19 among People Living With HIV/AIDS (PLWH) attending a tertiary public hospital in Salvador, Brazil, patients with active pulmonary tuberculosis and Hospital's Healthcare Workers (HCW), and to compare their SARS-CoV-2 antibody levels.
In this observational study we included 2294 participants from June 9, 2020 to August 10, 2021. IgG SARS-CoV-2 antibodies from all participants (275 PLWH, 42 with active tuberculosis and 1977 healthcare workers) were measured. Prevalence of COVID-19 and antibodies indexes were compared across groups.
We detected a higher prevalence of COVID-19 in patients with active tuberculosis (42.9%) than in PLWH (22.5%) or HCW (11.7%). Previously vaccinated participants with a COVID-19 history had median higher IgG antibody indexes (8.2; IQR: 5.5‒10) than those vaccinated who did not have COVID-19 until the time of this study (4.1; IQR: 1.6‒6.2, p < 0.001).
Prevalence of previous SARS-CoV-2 infection was higher among tuberculosis patients than that found in HCW and PLWH, but antibodies levels were similar across groups.
COVID-19 可能在不同人群中引发不同的临床表现，其中一些人群被认为感染 SARS-CoV-2 的风险较高。对于某些人群对感染的易感性知之甚少。
我们旨在确定巴西萨尔瓦多一家三级公立医院的 HIV/AIDS 感染者（PLWH）、活动性肺结核患者和医院医护人员（HCW）中 COVID-19 的患病率，并比较他们的 SARS-CoV-2 抗体水平。
在这项观察性研究中，我们纳入了 2020 年 6 月 9 日至 2021 年 8 月 10 日的 2294 名参与者。对所有参与者（275 名 PLWH、42 名活动性肺结核患者和 1977 名医护人员）的 IgG SARS-CoV-2 抗体进行了测量。比较了各组之间 COVID-19 的患病率和抗体指数。
我们发现活动性肺结核患者（42.9%）的 COVID-19 患病率高于 HIV/AIDS 感染者（22.5%）或 HCW（11.7%）。有 COVID-19 病史且接种过疫苗的参与者的 IgG 抗体指数中位数较高（8.2；IQR：5.5-10），而未发生 COVID-19 且在本研究期间接种过疫苗的参与者的 IgG 抗体指数中位数较低（4.1；IQR：1.6-6.2，p < 0.001）。
与 HCW 和 PLWH 相比，肺结核患者中既往 SARS-CoV-2 感染的患病率更高，但各组之间的抗体水平相似。
