Villaescusa R, Santos M N, Espinosa E, Hernández P
Haematologia (Budap). 1986;19(3):185-91.
Circulating immune complexes were investigated in sera of 100 patients with sickle cell anaemia (SCA) in different clinical stages, using inhibition of complement-dependent rosette formation (EAC rosette inhibition), anticomplementary activity, polyethylene glycol 6000 precipitation, immunoconglutinin titre, total haemolytic complement, C4 and C3d. A high positivity was observed in patients with hepatic crisis (75%) and cases with leg ulcers (43%) compared with painful crisis (12%) and asymptomatic (7%) patients. These results provide evidence for the presence of circulating immune complexes during leg ulcers and hepatic crisis in SCA.
采用补体依赖性玫瑰花结形成抑制试验（EAC玫瑰花结抑制试验）、抗补体活性、聚乙二醇6000沉淀法、免疫黏附素滴度、总溶血补体、C4和C3d，对100例处于不同临床阶段的镰状细胞贫血（SCA）患者血清中的循环免疫复合物进行了研究。与疼痛危象患者（12%）和无症状患者（7%）相比，肝危象患者（75%）和腿部溃疡患者（43%）的阳性率较高。这些结果为SCA患者腿部溃疡和肝危象期间循环免疫复合物的存在提供了证据。
