Ahmed Ishtkhar, Udawat Harsh Prasad, Ansari Mohsin, Yadav Rajeev, Vaishnav Sandeep, Agrawal Dinesh, Govil Anurag, Purohit Sunita
Santokba Institute of Gastroenterology, Santokba Durlabhji Memorial Hospital Cum Medical Research Institute, A-111, Shri Ram Marg, Shyam Nagar, Sodala, Jaipur, 302 019, India.
Department of Radiodiagnosis, Santokba Durlabhji Memorial Hospital Cum Medical Research Institute, Bhawani Singh Marg, Jaipur, 302 015, India.
Indian J Gastroenterol. 2023 Dec;42(6):824-832. doi: 10.1007/s12664-023-01436-7. Epub 2023 Oct 9.
The pathophysiology of postprandial distress syndrome includes impaired gastric accommodation, hypersensitivity to gastric distension and delayed gastric emptying. 2D-ultrasonography is one of the methods to assess gastric accommodation by measuring proximal gastric area and we evaluated its role in calculating proximal gastric area and thus assessing gastric accommodation in Indian patients with postprandial distress syndrome.
In a hospital-based comparative analysis, proximal gastric area was measured with 2D-ultrasonography of postprandial distress syndrome (PDS) patients and compared with healthy controls. Five readings were measured every five minutes till 25 minutes after 400 mL of vegetable soup. The Patient Assessment of Upper Gastrointestinal Disorders-Quality of Life (PAGI-QOL score) and diets aggravating PDS symptoms were studied through detailed questionnaires. Sample size was calculated at 80% study power and alpha error of 0.05 to be 30 subjects in each group.
The mean age of patients (18 males) vs. 30 healthy controls (25 males) was 40.8 ± 11.50 years vs. 36.37 ± 7.58, respectively, (p = 0.084). Proximal gastric area was significantly lower in patients versus healthy controls at five minutes (22.54 ± 2.77 vs. 30.66 ± 2.55 cm), 10 minutes (23.03 ± 2.45 vs. 31.10 ± 2.06 cm), 15 minutes (23.06 ± 2.27 vs. 30.31 ± 2.11 cm), 20 minutes (22.21 ± 2.31 vs. 29.73 ± 1.71 cm) and 25 minutes (22.02 ± 2.33 vs. 28.39 ± 1.55 cm); p < 0.001 at all intervals of time, indicating impaired gastric accommodation. The QOL was poor in all patients with PDS with mean PAGI-QOL score of 31.30 ± 15.05, median of 30, minimum score of 12 and maximum score of 66.
Measurement of proximal gastric area with 2D-ultrasonography is simple and non-invasive. Proximal gastric area in patients was lower than controls, indicating impaired gastric accommodation. Poor quality of life was universal in patients with postprandial distress syndrome.
餐后不适综合征的病理生理学包括胃容纳功能受损、对胃扩张过敏以及胃排空延迟。二维超声检查是通过测量胃近端面积来评估胃容纳功能的方法之一，我们评估了其在计算印度餐后不适综合征患者胃近端面积从而评估胃容纳功能方面的作用。
在一项基于医院的对比分析中，对餐后不适综合征（PDS）患者进行二维超声检查测量胃近端面积，并与健康对照者进行比较。在摄入400毫升蔬菜汤后，每隔5分钟测量一次，直至25分钟，共测量5次。通过详细问卷研究患者的上消化道疾病患者生活质量评估（PAGI - QOL评分）以及加重PDS症状的饮食情况。样本量按80%的检验效能和0.05的α错误计算，每组为30名受试者。
患者（18名男性）与30名健康对照者（25名男性）的平均年龄分别为40.8±11.50岁和36.37±7.58岁，（p = 0.084）。在5分钟（22.54±2.77 vs. 30.66±2.55平方厘米）、10分钟（23.03±2.45 vs. 31.10±2.06平方厘米）、15分钟（23.06±2.27 vs. 30.31±2.11平方厘米）、20分钟（22.21±2.31 vs. 29.73±1.71平方厘米）和25分钟（22.02±2.33 vs. 28.39±1.55平方厘米）时，患者的胃近端面积显著低于健康对照者；在所有时间间隔p均<0.001，表明胃容纳功能受损。所有PDS患者的生活质量较差，平均PAGI - QOL评分为31.30±15.05，中位数为30，最低分为12，最高分为66。
用二维超声检查测量胃近端面积简单且无创。患者的胃近端面积低于对照组，表明胃容纳功能受损。餐后不适综合征患者普遍生活质量较差。
