Fithian Eirene, Thivalapill Neil, Kosner John, Necheles Jonathan, Bilaver Lucy
Center for Food Allergy and Asthma Research, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Children's Healthcare Associates, Chicago, IL, USA.
Clin Cosmet Investig Dermatol. 2023 Oct 4;16:2757-2762. doi: 10.2147/CCID.S424077. eCollection 2023.
Dry scalp conditions affect a significant portion of the population, including children. Emerging evidence indicates the potential for improvement of atopic symptoms through altering the skin microbiome. Therefore, a topical treatment consisting of probiotic extracts, honey, turmeric, and vitamin B12 was manufactured to improve dry scalp symptomology through sustained balance of the microbiome.
This interventional clinical study aims to determine the safety and efficacy of the topical treatment in reducing dry scalp symptomology in children 1-17 years old with dry scalp symptoms.
Participants applied the topical dry scalp treatment 2-3 times per week for two weeks. Safety and efficacy of the topical treatment was determined through physician assessment using the validated Investigator's Global Assessment (IGA) scale and the Total Severity Scale (TSS) during pre- and post-treatment clinic visits as well as parent reports at baseline, 1-week midpoint, and 2-week exit.
Use of the topical treatment was associated with reduced symptoms of itchiness, dryness, irritation, and flakiness in children. The average IGA score was 3.0 at baseline and 2.0 after treatment, corresponding to a score difference of 1.0 (p < 0.001, 95% CI: 0.7, 1.2). The TSS score difference was 1.9 (p < 0.001, 95% CI: 1.4, 2.4). The total parent-reported scalp severity score decreased from 16.6 (95% CI: 14.8, 18.4) to 12.4 (p < 0.001, 95% CI: 11.0, 13.7) at 2-week exit.
Study results mirror those reported in a study conducted in adults and point to the safety and efficacy of this natural topical treatment in reducing dry scalp symptomology in children. Based on our data, the combination of probiotic extracts and other anti-inflammatory ingredients appears to improve overall scalp health and appearance, though further studies will need to be conducted to further elucidate the link between clinical improvement and a balanced scalp microbiome.
头皮干燥状况影响着包括儿童在内的相当一部分人群。新出现的证据表明,通过改变皮肤微生物群有可能改善特应性症状。因此,制备了一种由益生菌提取物、蜂蜜、姜黄和维生素B12组成的局部用治疗剂,以通过维持微生物群的平衡来改善头皮干燥症状。
这项干预性临床研究旨在确定该局部用治疗剂对1至17岁有头皮干燥症状儿童减轻头皮干燥症状的安全性和有效性。
参与者每周使用该局部用头皮治疗剂2至3次,持续两周。通过医生在治疗前和治疗后的门诊访视中使用经过验证的研究者整体评估(IGA)量表和总严重程度量表(TSS)进行评估,以及家长在基线、1周中点和2周结束时的报告,来确定该局部用治疗剂的安全性和有效性。
使用该局部用治疗剂与儿童瘙痒、干燥、刺激和脱屑症状的减轻有关。基线时平均IGA评分为3.0,治疗后为2.0,评分差异为1.0(p<0.001,95%CI:0.7,1.2)。TSS评分差异为1.9(p<0.001,95%CI:1.4,2.4)。在2周结束时,家长报告的头皮总严重程度评分从16.6(95%CI:14.8,18.4)降至12.4(p<0.001,95%CI:11.0,13.7)。
研究结果与在成人中进行的一项研究报告的结果相似,表明这种天然局部用治疗剂对减轻儿童头皮干燥症状具有安全性和有效性。根据我们的数据,益生菌提取物和其他抗炎成分的组合似乎可以改善头皮的整体健康状况和外观,不过还需要进行进一步的研究,以进一步阐明临床改善与头皮微生物群平衡之间的联系。