Thilak Swathi, Rajendra Aishwarya, Ganesh Veluri
SS Institute of Medical Sciences, Davanagere, Karnataka, India.
Department of Obstetrics and Gynaecology, Mavintop Hospital and IVF Center, Davangere, Karntaka - 577004, India.
Bioinformation. 2023 Feb 28;19(2):211-214. doi: 10.6026/97320630019211. eCollection 2023.
Gestational diabetes mellitus is most commonly observed in pregnant women and it was significantly linked with dyslipidemia, obesity and insulin resistance. The present study aimed to evaluate the association of obesity, insulin resistance risk of gestational diabetes mellitus. This cross sectional study included total ninety (90) subjects out of this 30 subjects with 1st trimester, another 30 subjects were considered 2nd trimester and remaining 30 were 3rd trimester. The fasting, post parandial blood sugars, glycated haemoglobin, lipid profile and insulin levels were measured and data was recorded. There was a significantly elevated levels of fasting and post parandial blood sugars, glycated haemoglobin, total cholesterol, triacylglycerol, very low density lipoprotein, low density lipoprotein (p = 0.0001**) in all the trimesters of gestational diabetes mellitus subjects. Additionally, we also observed significantly decreased levels of high density lipoprotein, insulin and HOMA-IR (p = 0.0001**) in all the trimesters of gestational diabetes mellitus subjects. The present study IR raises as the pregnancy progresses and it is linked to bad outcomes for both the mother and the fetus. All trimesters of gestational diabetes mellitus should be screened for IR, and early treatment may assist to lessen the resulting difficulties.
妊娠期糖尿病最常见于孕妇，并且它与血脂异常、肥胖和胰岛素抵抗显著相关。本研究旨在评估肥胖、胰岛素抵抗与妊娠期糖尿病风险之间的关联。这项横断面研究共纳入了90名受试者，其中30名处于孕早期，另外30名处于孕中期，其余30名处于孕晚期。测量了空腹血糖、餐后血糖、糖化血红蛋白、血脂谱和胰岛素水平并记录数据。妊娠期糖尿病受试者在所有孕周的空腹血糖、餐后血糖、糖化血红蛋白、总胆固醇、三酰甘油、极低密度脂蛋白、低密度脂蛋白水平均显著升高（p = 0.0001**）。此外，我们还观察到妊娠期糖尿病受试者在所有孕周的高密度脂蛋白、胰岛素和HOMA-IR水平均显著降低（p = 0.0001**）。本研究表明，胰岛素抵抗随着孕周的增加而升高，并且它与母婴不良结局相关。妊娠期糖尿病的所有孕周都应筛查胰岛素抵抗，早期治疗可能有助于减轻由此产生的困难。
