Culture Collection & Research Institute, SYNBIO TECH Incorporation, Kaohsiung, Taiwan.
Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan, Taiwan.
Physiol Rep. 2023 Oct;11(19):e15835. doi: 10.14814/phy2.15835.
Consumption of Lactiplantibacillus plantarum TWK10 (TWK10) has beneficial probiotic effects, improves exercise endurance performance, regulates body composition, and mitigates aging-related problems in mice and humans. Here, we investigated the effects of heat-killed TWK10 on exercise endurance performance, muscle weight and strength, fatigue, and body composition in a double-blind, placebo-controlled clinical trial. Thirty healthy males aged 20-40 years were assigned to the Control group or heat-killed TWK10 group (TWK10-HK) in a balanced order according to each individual's initial maximal oxygen uptake. After 6-week administration, the exercise endurance time in the TWK10-HK was significantly increased (p = 0.0028) compared with that in the Control group. The grip strength on the right and left hands of the subjects was significantly increased (p = 0.0002 and p = 0.0140, respectively) in the TWK10-HK compared with that in the Control group. Administration of heat-killed TWK10 resulted in a significant increase (p = 0.0275) in muscle weight. After 6-week administration, serum lactate, and ammonia levels were significantly lower in the TWK10-HK group than in the Control group during the exercise and recovery periods. These findings demonstrate that heat-killed TWK10 has significant potential to be used as a postbiotic for humans.
植物乳杆菌 TWK10（TWK10）的消费具有有益的益生菌作用，可提高运动耐力表现，调节身体成分，并减轻小鼠和人类的与衰老相关的问题。在这里，我们根据每个人的初始最大摄氧量，在一项双盲、安慰剂对照的临床试验中，研究了热处理的 TWK10 对运动耐力表现、肌肉重量和力量、疲劳以及身体成分的影响。将 30 名年龄在 20-40 岁的健康男性根据个体的初始最大耗氧量，按照平衡顺序分为对照组或热处理 TWK10 组（TWK10-HK）。经过 6 周的给药后，TWK10-HK 组的运动耐力时间明显延长（p=0.0028）。与对照组相比，TWK10-HK 组受试者右手和左手的握力显著增加（p=0.0002 和 p=0.0140）。热处理 TWK10 的给药导致肌肉重量显著增加（p=0.0275）。经过 6 周的给药后，TWK10-HK 组在运动和恢复期的血清乳酸和氨水平明显低于对照组。这些发现表明，热处理的 TWK10 具有作为后生元用于人类的巨大潜力。
