2 型糖尿病患者抗阻训练的剂量-反应关系：随机对照试验的荟萃分析。
Dose-response relationships of resistance training in Type 2 diabetes mellitus: a meta-analysis of randomized controlled trials.
机构信息
Joint Surgery and Sport Medicine Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
Nursing Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
出版信息
Front Endocrinol (Lausanne). 2023 Sep 25;14:1224161. doi: 10.3389/fendo.2023.1224161. eCollection 2023.
BACKGROUND
Globally, type 2 diabetes mellitus (T2DM) accounts for approximately 90% of diabetes cases. Resistance training (RT) is frequently employed to diminish Glycated Hemoglobin (HbA1c) and Fast Blood Glucose (FBG) levels in T2DM patients. Yet, the specific dose-response relationships between RT variables such as training duration, frequency, and intensity for T2DM remain under-researched.
OBJECTIVES
This meta-analysis aimed to elucidate the overarching effects of RT on HbA1c and FBG metrics and to provide dose-response relationships of RT variables. This was achieved by examining randomized controlled trials (RCTs) that reported reductions in HbA1c and FBG among T2DM patients.
METHODS
Comprehensive literature searches were conducted up to 25 February 2023 across databases including EMBASE, Pubmed, Cochrane, CENTRAL, Web of Science, CNKI, Wanfang Data, VIP Database for Chinese Technical Periodicals, and the Chinese Biomedical Database. The Physical Therapy Evidence Database (PEDro) was leveraged to appraise the quality of selected studies based on predefined inclusion and exclusion criteria. The meta-analysis was conducted using Stata 16.
RESULTS
26 studies that include 1336 participants met the criteria for inclusion. RT significantly reduced HbA1c and FBG levels in comparison to control groups (P<0.05). Meta-regression analyses revealed that the number of repetitions per set (p=0.034) was a significant predictor of RT's efficacy on HbA1c. Subgroup analyses indicated that the most pronounced reductions in HbA1c and FBG occurred with a training duration of 12-16 weeks, intensities of 70-80% of 1 RM, training frequencies of 2-3 times per week, 3 sets per session, 8-10 repetitions per set, and less than a 60-second rest interval.
CONCLUSION
The beneficial impact of RT on HbA1c and FBG in T2DM patients is affirmed by this systematic review and meta-analysis. Moreover, the critical training parameters identified in this study are pivotal in enhancing HbA1c and FBG reductions, providing a reference for clinical staff to formulate RT exercise regiments for T2DM patients.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero, identifier CRD42023414616.
背景
在全球范围内，2 型糖尿病（T2DM）约占糖尿病病例的 90%。抗阻训练（RT）常用于降低 T2DM 患者的糖化血红蛋白（HbA1c）和快速血糖（FBG）水平。然而，RT 变量（如训练持续时间、频率和强度）与 T2DM 之间的具体剂量反应关系仍研究不足。
目的
本荟萃分析旨在阐明 RT 对 HbA1c 和 FBG 指标的总体影响，并提供 RT 变量的剂量反应关系。这是通过检查报告 T2DM 患者 HbA1c 和 FBG 降低的随机对照试验（RCT）来实现的。
方法
全面的文献检索截至 2023 年 2 月 25 日，在包括 EMBASE、PubMed、Cochrane、CENTRAL、Web of Science、CNKI、万方数据、维普中文科技期刊数据库和中国生物医学文献数据库在内的数据库中进行。利用物理治疗证据数据库（PEDro）根据预先设定的纳入和排除标准评估选定研究的质量。使用 Stata 16 进行荟萃分析。
结果
26 项研究，共纳入 1336 名参与者，符合纳入标准。与对照组相比，RT 显著降低了 HbA1c 和 FBG 水平（P<0.05）。元回归分析显示，每组重复次数（p=0.034）是 RT 对 HbA1c 疗效的一个显著预测因子。亚组分析表明，HbA1c 和 FBG 降低最显著的是训练持续时间为 12-16 周、强度为 1 RM 的 70-80%、每周训练频率为 2-3 次、每次训练 3 组、每组 8-10 次重复和休息间隔小于 60 秒。
结论
本系统评价和荟萃分析证实了 RT 对 T2DM 患者 HbA1c 和 FBG 的有益影响。此外，本研究确定的关键训练参数对于增强 HbA1c 和 FBG 的降低至关重要，为临床工作人员为 T2DM 患者制定 RT 运动方案提供了参考。
系统评价注册
https://www.crd.york.ac.uk/prospero，标识符 CRD42023414616。
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