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肿瘤重症监护病房中的血糖变异性与死亡率

Glycemic variability and mortality in oncologic intensive care units.

作者信息

Oliveira Aretha Pereira de, Castro Mariana da Silva, Lima Dalmo Valério Machado de

机构信息

Universidade Federal Fluminense. Niterói, Rio de Janeiro, Brazil.

Universidade Federal do Estado do Rio de Janeiro. Rio de Janeiro, Rio de Janeiro, Brazil.

出版信息

Rev Bras Enferm. 2023 Oct 9;76(4):e20220812. doi: 10.1590/0034-7167-2022-0812. eCollection 2023.

DOI:10.1590/0034-7167-2022-0812
PMID:37820156
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10561948/
Abstract

OBJECTIVE

This study aimed to investigate the association between glycemic variability and mortality in patients admitted to oncologic intensive care units.

METHODS

A retrospective cohort study was conducted using a convenience sample of 30 medical records of patients over 18 years of age of both sexes. Glycemic variability was measured using the standard deviation and general amplitude. Statistical analysis was performed using the receiver operating characteristic (ROC) curve and the area under the curve (AUC). The significance level (α) was set at 5% with a confidence interval (CI) of 95%.

RESULTS

The study included 14 male patients (46.67%) with a mean age of 60±15 years. A total of 1503 blood glucose samples were collected. The AUC analysis for the standard deviation did not show a statistically significant result (p=.966; 95% CI=[0.283, 0.726]). In contrast, the general amplitude had a statistically significant association with mortality (p=.049; 95% CI=[0.514, 0.916]).

CONCLUSIONS

This study found that glycemic variability measured by the general amplitude was significantly associated with patient mortality in oncologic intensive care units. These findings suggest that monitoring glycemic variability may be an important factor in the management of critically ill patients in oncologic intensive care units.

摘要

目的

本研究旨在调查肿瘤重症监护病房患者血糖变异性与死亡率之间的关联。

方法

采用回顾性队列研究,便利抽样选取30份18岁以上男女患者的病历。使用标准差和总体振幅来测量血糖变异性。采用受试者工作特征(ROC)曲线和曲线下面积(AUC)进行统计分析。显著性水平(α)设定为5%,置信区间(CI)为95%。

结果

该研究纳入了14名男性患者(46.67%),平均年龄为60±1 ... 更多内容请查看完整译文。

注

你提供的原文中“平均年龄为60±15 years”后面表述不完整,我按照完整的格式进行了翻译示例。完整的内容应该是“平均年龄为60±15岁” 。

完整译文

目的

本研究旨在调查肿瘤重症监护病房患者血糖变异性与死亡率之间的关联。

方法

采用回顾性队列研究,便利抽样选取30份18岁以上男女患者的病历。使用标准差和总体振幅来测量血糖变异性。采用受试者工作特征(ROC)曲线和曲线下面积(AUC)进行统计分析。显著性水平(α)设定为5%,置信区间(CI)为95%。

结果

该研究纳入了14名男性患者(46.67%),平均年龄为60±15岁。共采集了1503份血糖样本。标准差的AUC分析未显示出统计学上的显著结果(p = .966;95% CI = [0.283, 0.726])。相比之下,总体振幅与死亡率有统计学上的显著关联(p = .049;95% CI = [0.514, 0.916])。

结论

本研究发现,总体振幅测量的血糖变异性与肿瘤重症监护病房患者死亡率显著相关。这些发现表明,监测血糖变异性可能是肿瘤重症监护病房重症患者管理中的一个重要因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0d/10561948/24aa62efa5ab/0034-7167-reben-76-04-e20220812-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0d/10561948/e061d4f8f25f/0034-7167-reben-76-04-e20220812-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0d/10561948/e849ddfef1f8/0034-7167-reben-76-04-e20220812-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0d/10561948/24aa62efa5ab/0034-7167-reben-76-04-e20220812-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0d/10561948/e061d4f8f25f/0034-7167-reben-76-04-e20220812-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0d/10561948/e849ddfef1f8/0034-7167-reben-76-04-e20220812-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0d/10561948/24aa62efa5ab/0034-7167-reben-76-04-e20220812-gf03.jpg

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本文引用的文献

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Diabetic hyperglycemia promotes primary tumor progression through glycation-induced tumor extracellular matrix stiffening.糖尿病性高血糖通过糖基化诱导的肿瘤细胞外基质变硬促进原发性肿瘤进展。
Sci Adv. 2022 Nov 16;8(46):eabo1673. doi: 10.1126/sciadv.abo1673. Epub 2022 Nov 18.
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Stress-Induced Hyperglycemia: Consequences and Management.应激性高血糖:后果与管理
Cureus. 2022 Jul 10;14(7):e26714. doi: 10.7759/cureus.26714. eCollection 2022 Jul.
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Association of Blood Glucose Level and Glycemic Variability With Mortality in Sepsis Patients During ICU Hospitalization.
血糖水平和血糖变异性与 ICU 住院期间脓毒症患者死亡率的关系。
Front Public Health. 2022 Apr 29;10:857368. doi: 10.3389/fpubh.2022.857368. eCollection 2022.
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Acute glycemic variability and risk of mortality in patients with sepsis: a meta-analysis.脓毒症患者的急性血糖变异性与死亡风险:一项荟萃分析
Diabetol Metab Syndr. 2022 Apr 23;14(1):59. doi: 10.1186/s13098-022-00819-8.
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Breast Cancer, Diabetes Mellitus and Glucagon-Like Peptide-1 Receptor Toward Exploring Their Possible Associations.乳腺癌、糖尿病和胰高血糖素样肽-1 受体——探索它们可能的关联。
Breast Cancer Res Treat. 2021 Aug;189(1):39-48. doi: 10.1007/s10549-021-06288-3. Epub 2021 Jul 2.
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The prognostic role of hyperglycemia and glucose variability in covid-related acute respiratory distress Syndrome.高血糖和血糖变异性在新冠相关急性呼吸窘迫综合征中的预后作用。
Diabetes Res Clin Pract. 2021 May;175:108789. doi: 10.1016/j.diabres.2021.108789. Epub 2021 Apr 1.
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Hyperglycemia and Chemoresistance in Breast Cancer: From Cellular Mechanisms to Treatment Response.乳腺癌中的高血糖与化疗耐药性:从细胞机制到治疗反应
Front Oncol. 2021 Feb 25;11:628359. doi: 10.3389/fonc.2021.628359. eCollection 2021.
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Glycemic variability: adverse clinical outcomes and how to improve it?血糖变异性:不良临床结局及其改善方法?
Cardiovasc Diabetol. 2020 Jul 4;19(1):102. doi: 10.1186/s12933-020-01085-6.
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Admission Hyperglycemia as a Predictor of Mortality in Acute Heart Failure: Comparison between the Diabetics and Non-Diabetics.入院时高血糖作为急性心力衰竭死亡率的预测指标:糖尿病患者与非糖尿病患者的比较
J Clin Med. 2020 Jan 6;9(1):149. doi: 10.3390/jcm9010149.
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