Jagtap Anil P, Mamone Salvatore, Glöggler Stefan
NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Center for Biostructural Imaging of Neurodegeneration, University Medicine Göttingen, Göttingen, Germany.
Magn Reson Chem. 2023 Dec;61(12):674-680. doi: 10.1002/mrc.5402. Epub 2023 Oct 11.
Enhancing magnetic resonance signal via hyperpolarization techniques enables the real-time detection of metabolic transformations even in vivo. The use of para-hydrogen to enhance C-enriched metabolites has opened a rapid pathway for the production of hyperpolarized metabolites, which usually requires specialized equipment. Metabolite precursors that can be hyperpolarized and converted into metabolites at any given field would open up opportunities for many labs to make use of this technology because already existing hardware could be used. We report here on the complete synthesis and hyperpolarization of suitable precursor molecules of the side-arm hydrogenation approach. The better accessibility to such side-arms promises that the para-hydrogen approach can be implemented in every lab with existing two channel NMR spectrometers for H and C independent of the magnetic field.
通过超极化技术增强磁共振信号，即使在体内也能实现对代谢转化的实时检测。利用仲氢增强富含碳的代谢物，为超极化代谢物的产生开辟了一条快速途径，而这通常需要专门的设备。能够在任何给定磁场下被超极化并转化为代谢物的代谢物前体，将为许多实验室利用这项技术创造机会，因为可以使用现有的硬件。我们在此报告侧链氢化方法中合适前体分子的全合成及超极化情况。这种侧链更好的可及性保证了仲氢方法能够在每个配备有用于氢和碳的现有双通道核磁共振光谱仪的实验室中实施，而与磁场无关。
