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利用基于碳的电化学生物传感器颠覆癌症监测。

Revolutionizing cancer monitoring with carbon-based electrochemical biosensors.

机构信息

School of Resources and Environment, University of Electronic Science and Technology of China, P.O. Box 611731, Xiyuan Ave, Chengdu, PR China.

School of Resources and Environment, University of Electronic Science and Technology of China, P.O. Box 611731, Xiyuan Ave, Chengdu, PR China; School of Engineering, Lebanese American University, Byblos, Lebanon.

出版信息

Environ Res. 2023 Dec 15;239(Pt 2):117368. doi: 10.1016/j.envres.2023.117368. Epub 2023 Oct 10.

Abstract

Cancer monitoring plays a critical role in improving patient outcomes by providing early detection, personalized treatment options, and treatment response tracking. Carbon-based electrochemical biosensors have emerged in recent years as a revolutionary technology with the potential to revolutionize cancer monitoring. These sensors are useful for clinical applications because of their high sensitivity, selectivity, rapid response, and compatibility with miniaturized equipment. This review paper gives an in-depth look at the latest developments and the possibilities of carbon-based electrochemical sensors in cancer surveillance. The essential principles of carbon-based electrochemical sensors are discussed, including their structure, operating mechanisms, and critical qualities that make them suited for cancer surveillance. Furthermore, we investigate their applicability in detecting specific cancer biomarkers, evaluating therapy responses, and detecting cancer recurrence early. Additionally, a comparison of carbon-based electrochemical sensor performance measures, including sensitivity, selectivity, accuracy, and limit of detection, is presented in contrast to existing monitoring methods and upcoming technologies. Finally, we discuss prospective tactics, future initiatives, and commercialization opportunities for improving the capabilities of these sensors and integrating them into normal clinical practice. The review highlights the potential impact of carbon-based electrochemical sensors on cancer diagnosis, treatment, and patient outcomes, as well as the importance of ongoing research, collaboration, and validation studies to fully realize their potential in revolutionizing cancer monitoring.

摘要

癌症监测通过早期发现、个性化治疗选择以及治疗反应跟踪,对改善患者预后起着至关重要的作用。近年来,碳基电化学生物传感器作为一种具有变革性的技术出现,有可能彻底改变癌症监测。由于其高灵敏度、选择性、快速响应以及与小型化设备的兼容性,这些传感器在临床应用中非常有用。

本综述论文深入探讨了碳基电化学传感器在癌症监测方面的最新进展和可能性。文中讨论了碳基电化学传感器的基本原理,包括它们的结构、工作机制以及使它们适合癌症监测的关键特性。此外,我们研究了它们在检测特定癌症生物标志物、评估治疗反应以及早期发现癌症复发方面的适用性。

此外,还对碳基电化学传感器的性能指标(包括灵敏度、选择性、准确性和检测限)与现有监测方法和新兴技术进行了比较。最后,我们讨论了改进这些传感器性能并将其集成到常规临床实践中的未来策略、新举措和商业化机会。

本综述强调了碳基电化学传感器在癌症诊断、治疗和患者预后方面的潜在影响,以及持续研究、合作和验证研究的重要性,以充分发挥其在癌症监测方面的变革潜力。

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