Cao Zhongqiang, Fu Zhengran, Liu Ying, Liu Ting, Zhan Min, Liu Xiaoya, Cheng Xiaoling
Department of Pharmacy, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Department of Pharmacy, Shenzhen Children's Hospital, Shenzhen 518038, China.
Saudi Pharm J. 2023 Nov;31(11):101801. doi: 10.1016/j.jsps.2023.101801. Epub 2023 Sep 26.
: Limited data exists on the use of rivaroxaban for the treatment of pediatric patients. This report presents a case of probable rivaroxaban-induced Erythema Multiforme in Children. A female patient aged 5.5 years with antiphospholipid syndrome (APS) was administered oral rivaroxaban tablets 2.5 mg twice a day for 16 days. Subsequently, the patient developed a slight itching sensation on both feet and buttocks without an apparent cause. The following day, erythema multiforme appeared across the body in a scattered pattern. The erythema presented higher than the skin surface and partially merged into areas of the skin. Following an increase in the extent and degree of the erythema, all oral medications were ceased. Treatment with dexamethasone sodium phosphate injection, mometasone furoate cream, and mucopolysaccharide polysulfate cream resulted in an improvement of erythema multiforme. The erythema diminished and did not deteriorate subsequent to changing from rivaroxaban tablets to warfarin sodium tablets, and receiving nadroparin calcium injection.
关于利伐沙班用于治疗儿科患者的数据有限。本报告介绍了一例儿童可能由利伐沙班引起的多形红斑病例。一名5.5岁患有抗磷脂综合征（APS）的女性患者，每天口服2.5毫克利伐沙班片，一日两次，共服用16天。随后，患者双脚和臀部出现轻微瘙痒感，无明显诱因。第二天，全身散在出现多形红斑。红斑高出皮肤表面，部分融合成片。随着红斑范围和程度的增加，所有口服药物均停药。使用地塞米松磷酸钠注射液、糠酸莫米松乳膏和多磺酸粘多糖乳膏治疗后，多形红斑有所改善。从利伐沙班片换用华法林钠片并接受那屈肝素钙注射液治疗后，红斑消退且未再恶化。
