Pharmaceutics Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt.
Pharmacology and Toxicology Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt.
Pharm Dev Technol. 2023 Nov;28(9):884-895. doi: 10.1080/10837450.2023.2270057. Epub 2023 Nov 15.
Asses the wound healing activity of Polyvinyl alcohol - Deflazacort (PVA-DEF) nanofibers mats synthesized by electrospinning technology.
PVA-DEF nanofiber mats were created with various PVA polymer concentrations using an electrospinning process. The morphological features and diameter of the electrospun nanofibrous mats were investigated using scanning electron microscopy (SEM). The DEF release rate from PVA electrospun nanofibrous mats was evaluated. In addition to assessing wound healing activity , histological, and immunochemical tests were conducted.
Results revealed a uniform and smooth surface of the fiber with an average diameter of the selected fibers of 533.9 nm ± 45.83. Also, PVA electrospun nanofiber mats showed an initial burst release of more than 50% of the DEF in 1 h, and the rest of the DEF was released gradually for up to 480 min. Fickian diffusion is the main DEF release mechanism from PVA electrospun nanofiber mats. In male Wistar albino rats with 1 cm excision wounds, studies revealed a significant improvement in wound healing rate modulation of tumor necrosis factor-alpha (TNF-α) and vascular endothelial growth factor (VEGF) expression.
PVA-DEF nanofiber mats can be used effectively for improving wound healing.
评估电纺技术合成的聚乙烯醇-地夫可特（PVA-DEF）纳米纤维垫的伤口愈合活性。
通过电纺工艺，使用不同 PVA 聚合物浓度制备 PVA-DEF 纳米纤维垫。使用扫描电子显微镜（SEM）研究电纺纳米纤维垫的形态特征和直径。评估 PVA 电纺纳米纤维垫中 DEF 的释放率。除了评估伤口愈合活性外，还进行了组织学和免疫化学测试。
结果显示纤维表面均匀光滑，所选纤维的平均直径为 533.9nm±45.83nm。此外，PVA 电纺纳米纤维垫在 1 小时内释放超过 50%的 DEF，其余 DEF 逐渐释放长达 480 分钟。Fickian 扩散是 PVA 电纺纳米纤维垫中 DEF 释放的主要机制。在 1cm 切除伤口的雄性 Wistar 白化大鼠中，研究表明 TNF-α和血管内皮生长因子（VEGF）表达的伤口愈合率调节有显著改善。
PVA-DEF 纳米纤维垫可有效用于改善伤口愈合。
