Guetta E, Ron D, Tal J
J Gen Virol. 1986 Nov;67 ( Pt 11):2549-54. doi: 10.1099/0022-1317-67-11-2549.
The replication of the autonomous parvovirus, minute virus of mice (MVM), requires mitotically active cells and depends on certain factors expressed by cells of particular differentiated phenotype. As an approach to the understanding of these helper functions, we studied the interaction of the fibrotropic [MVM(p)] and the lymphotropic [MVM(i)] strains of MVM with two differentiated cell lines from mouse testicular epithelial origins. The relative support given to viral expression by these cell lines varied extensively. Cells from Sertoli origin (TM4) were permissive to MVM(p) but were mostly restrictive to MVM(i). The other cell line, of Leydig cell origin (TM3), was highly restrictive to both viral strains, but the blocks to their growth in these cells were localized at different stages of their growth cycle, suggesting that the replication of MVM in these cells requires tissue-specific helper functions during at least two stages of viral replication.
自主细小病毒——小鼠微小病毒（MVM）的复制需要有丝分裂活跃的细胞，并依赖于特定分化表型细胞所表达的某些因子。作为理解这些辅助功能的一种方法，我们研究了亲纤维型[MVM(p)]和亲淋巴型[MVM(i)]的MVM毒株与两种源自小鼠睾丸上皮的分化细胞系之间的相互作用。这些细胞系对病毒表达的相对支持程度差异很大。支持细胞来源的细胞（TM4）对MVM(p)敏感，但对MVM(i)大多具有限制性。另一种细胞系，即睾丸间质细胞来源的（TM3），对两种病毒毒株都具有高度限制性，但病毒在这些细胞中生长的阻滞发生在其生长周期的不同阶段，这表明MVM在这些细胞中的复制在病毒复制的至少两个阶段需要组织特异性辅助功能。
