Mousset S, Rommelaere J
Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode-Saint-Genèse, Belgium.
Virus Res. 1988 Feb;9(2-3):107-17. doi: 10.1016/0168-1702(88)90026-3.
Transformation of mouse fibroblasts by simian virus 40 (SV40) or certain oncogenes enhances their susceptibility to the lytic replication of Minute virus of mice (MVM), a non-defective parvovirus. It was investigated whether this cytotoxic action of MVM can also be potentiated by two types of incomplete and reversible cell transformation induced either by SV40 infection or by exposure to the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Although the latter two treatments trigger the expression of several traits of the transformed phenotype, they do not significantly enhance cell permissiveness to MVM.
猿猴病毒40（SV40）或某些癌基因对小鼠成纤维细胞的转化增强了它们对小鼠微小病毒（MVM，一种无缺陷细小病毒）裂解性复制的敏感性。研究了MVM的这种细胞毒性作用是否也能被由SV40感染或暴露于肿瘤启动子12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）诱导的两种不完全且可逆的细胞转化所增强。尽管后两种处理引发了转化表型的若干特征的表达，但它们并未显著增强细胞对MVM的易感性。
