Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran.
Centre for Perinatal Research, Academic Unit of Population and Lifespan Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
PLoS One. 2023 Oct 13;18(10):e0292734. doi: 10.1371/journal.pone.0292734. eCollection 2023.
The current meta-analysis investigated the effects of exercise training on circulating adhesion molecules i.e. soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in adults.
PubMed, Web of Science, Scopus and Embase were searched to identify original articles, published in English languages journal from inception up to 31 August 2023 that compared the effects of exercise training with non-exercising control on sICAM-1 and sVCAM-1 in adults. Standardized mean differences (SMDs) and 95% CIs were calculated using random-effect models.
Twenty-three studies including 31 intervention arms and involving 1437 subjects were included in the meta-analysis. Exercise training effectively reduced sICAM-1 [SMD: -0.33 (95% CI -0.56 to -0.11), p = 0.004; I2 = 56.38%, p = 0.001; 23 intervention arms]. Subgroup analyses showed that sICAM-1 decreased in adults with age <60 years (p = 0.01) and BMI ≥ 27 kg/m2 (p = 0.002) and those with metabolic disorders (p = 0.004) and cardiovascular diseases (p = 0.005). In addition, aerobic (p = 0.02) and resistance training (p = 0.007) are effective in reducing sICAM-1. However, exercise training did not indicate a superior effect on sVCAM-1 [SMD: -0.12 (95% CI -0.29 to 0.05), p = 0.17; I2 = 36.29%, p = 0.04; 23 intervention arms].
Our results show that exercise training reduces sICAM-1, but not for sVCAM-1, where both aerobic and resistance training is effective in reducing sICAM-1 in adults with metabolic disorders and cardiovascular diseases.
The current meta-analysis was registered at www.crd.york.ac.uk/prospero with ID registration number: CRD42023410474.
本荟萃分析研究了运动训练对循环黏附分子即可溶性细胞间黏附分子-1（sICAM-1）和可溶性血管细胞黏附分子-1（sVCAM-1）在成年人中的影响。
检索了 PubMed、Web of Science、Scopus 和 Embase，以确定从成立到 2023 年 8 月 31 日发表的比较运动训练与非运动对照组对成年人 sICAM-1 和 sVCAM-1 影响的英文期刊原始文章。使用随机效应模型计算标准化均数差（SMD）和 95%置信区间。
荟萃分析纳入了 23 项研究共 31 个干预组，涉及 1437 名受试者。运动训练可有效降低 sICAM-1[SMD：-0.33（95%CI-0.56 至-0.11），p=0.004；I2=56.38%，p=0.001；23 个干预组]。亚组分析显示，sICAM-1 在年龄<60 岁（p=0.01）和 BMI≥27kg/m2（p=0.002）的成年人、合并代谢紊乱（p=0.004）和心血管疾病（p=0.005）的成年人中降低。此外，有氧运动（p=0.02）和抗阻运动（p=0.007）可有效降低 sICAM-1。然而，运动训练对 sVCAM-1 没有显示出优势影响[SMD：-0.12（95%CI-0.29 至 0.05），p=0.17；I2=36.29%，p=0.04；23 个干预组]。
我们的结果表明，运动训练可降低 sICAM-1，但不能降低 sVCAM-1，有氧运动和抗阻运动均可有效降低合并代谢紊乱和心血管疾病的成年人的 sICAM-1。
本荟萃分析已在 www.crd.york.ac.uk/prospero 上注册，注册号为 CRD42023410474。
