帕金森病中与“剂量末期恶化”相关的情绪变化：一项对照研究。
Mood changes associated with "end-of-dose deterioration" in Parkinson's disease: a controlled study.
作者信息
Cantello R, Gilli M, Riccio A, Bergamasco B
出版信息
J Neurol Neurosurg Psychiatry. 1986 Oct;49(10):1182-90. doi: 10.1136/jnnp.49.10.1182.
Abstract
Fluctuations of mood and psychic activation were assessed in relation to "mobile" and "immobile" periods in 18 patients with Parkinson's disease presenting typical "end-of-dose deterioration". Twelve subjects with chronic but active rheumatoid arthritis presenting increased physical disability due to severe morning joint stiffness with a repetitive pattern of mobile and immobile periods acted as controls. The overall degree of disability and its fluctuations were close enough in the two groups for fair comparison of changes in affective behaviour. Temporary immobility was accompanied by adverse changes of mood and activation, which were significantly more marked in the Parkinson's disease group than in the controls, though to a lesser extent in those Parkinson's disease patients rated depressed even in their mobile periods. The possible correlation between mood changes and fluctuations of central dopaminergic function in the Parkinson's disease patients is discussed.
摘要
对18例表现出典型“剂末恶化”的帕金森病患者，就其“活动”和“非活动”期评估情绪波动和精神激活情况。12例患有慢性但活动性类风湿关节炎的受试者，因严重的晨僵导致身体残疾加重，且活动期和非活动期呈重复模式，作为对照组。两组的整体残疾程度及其波动情况相近，足以对情感行为变化进行合理比较。暂时的非活动伴有情绪和激活的不良变化，在帕金森病组中比对照组明显更显著，尽管在那些即使在活动期也被评定为抑郁的帕金森病患者中程度较轻。讨论了帕金森病患者情绪变化与中枢多巴胺能功能波动之间的可能相关性。
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