Mayeux R, Stern Y, Cote L, Williams J B
Neurology. 1984 May;34(5):642-6. doi: 10.1212/wnl.34.5.642.
Depression is a common symptom in patients with Parkinson's disease. It is not related to the severity of the motor symptoms or changes in dopamine metabolism and does not improve on treatment with dopamine agonists. Alterations in serotonin metabolism are found in primary (endogenous) depression. The brain content of serotonin in Parkinson's disease is also reduced, but this has not been related to any manifestation of the disorder. We found that the CSF content of the major metabolite of serotonin, 5-hydroxyindoleacetic acid, was lower in depressed than in nondepressed parkinsonians. The data suggest that the alterations in serotonin metabolism in Parkinson's disease identify a subgroup of patients who are prone to depression.
抑郁症是帕金森病患者的常见症状。它与运动症状的严重程度或多巴胺代谢变化无关，用多巴胺激动剂治疗也无法改善。5-羟色胺代谢改变见于原发性（内源性）抑郁症。帕金森病患者大脑中的5-羟色胺含量也会降低，但这与该疾病的任何表现均无关联。我们发现，与未患抑郁症的帕金森病患者相比，患抑郁症的帕金森病患者脑脊液中5-羟色胺的主要代谢产物5-羟吲哚乙酸的含量更低。这些数据表明，帕金森病患者5-羟色胺代谢的改变确定了一组易患抑郁症的患者亚群。
