The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Department of Oral and Maxillofacial-Head and Neck Oncology, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, China.
Biomed Res Int. 2022 Jun 28;2022:6457840. doi: 10.1155/2022/6457840. eCollection 2022.
The burden of oral cancer (OC) is closely related to economic development. We aimed to evaluate the burden of OC at different stages of economic development in China in terms of incidence, mortality, and mortality-to-incidence ratio (MIR) from 1990 to 2019. Data on cancer in China from 1990 to 2019 were obtained from the Global Burden of Disease 2019. Based on human development index (HDI), Chinese economic development was divided into three stages: low, medium, and high HDI stages. Mann-Whitney -test was used to evaluate the differences in age-standardised incidence rates (ASIR), age-standardised mortality rates (ASMR), and MIR at various stages of HDI. Correlation and regression tests were conducted to examine the association amongst ASIR, ASMR, MIR, and HDI in OC. The estimated annual percentage changes (EAPCs) were calculated to assess the trend of ASIR, ASMR, and MIR. Significant differences were observed in terms of ASIR, ASMR, and MIR between groups ( < 0.001). The values of both sexes in the low HDI stage were lower than those of the medium and high HDI stages, except for MIR, in which the low HDI stage was the highest ( < 0.05). ASIR and ASMR of OC in males at the medium HDI stage showed the fastest growth rate with EAPC values of 5.64 (95% confidence interval, 95% CI, 5.20 to 6.08) and 4.42 (95% CI, 4.01 to 4.82), respectively. A strong positive correlation exists between HDI and ASIR ( = 0.96) and ASMR ( = 0.91) in both sexes from 1990 to 2019. During the high HDI stage, the ASIR and ASMR of OC were at a high level, but the ASIR halted the uptrend trend and ASMR showed a decreasing trend. Therefore, the HDI index has been positively correlated with the ASIR and ASMR of OC in China in the past 30 years, but this relationship may not be sustained as the economy develops. The health department should continue to allocate additional resources for the prevention and treatment of OC.
口腔癌（OC）的负担与经济发展密切相关。我们旨在评估 1990 年至 2019 年中国不同经济发展阶段 OC 的负担，包括发病率、死亡率和死亡率与发病率比（MIR）。1990 年至 2019 年中国癌症数据来自全球疾病负担 2019 年研究。根据人类发展指数（HDI），中国经济发展分为低、中、高 HDI 阶段。采用 Mann-Whitney -test 评估不同 HDI 阶段的年龄标准化发病率（ASIR）、年龄标准化死亡率（ASMR）和 MIR 的差异。进行相关和回归检验以研究 OC 中 ASIR、ASMR 和 MIR 之间的关联。计算估计的年变化百分比（EAPC）以评估 ASIR、ASMR 和 MIR 的趋势。组间 ASIR、ASMR 和 MIR 存在显著差异（<0.001）。低 HDI 阶段男女的 ASIR 和 ASMR 值均低于中高 HDI 阶段，除了 MIR 值外，低 HDI 阶段最高（<0.05）。中 HDI 阶段男性 OC 的 ASIR 和 ASMR 增长率最快，EAPC 值分别为 5.64（95%置信区间，95%CI，5.20 至 6.08）和 4.42（95%CI，4.01 至 4.82）。1990 年至 2019 年，男女两性的 HDI 与 ASIR（=0.96）和 ASMR（=0.91）呈强正相关。在高 HDI 阶段，OC 的 ASIR 和 ASMR 处于较高水平，但 ASIR 停止上升趋势，ASMR 呈下降趋势。因此，在过去 30 年中，HDI 指数与中国 OC 的 ASIR 和 ASMR 呈正相关，但随着经济的发展，这种关系可能不会持续。卫生部门应继续为 OC 的预防和治疗分配额外资源。
