吸烟与膝骨关节炎软骨丢失的关系：来自两个纵向队列的数据。
Association of smoking with cartilage loss of knee osteoarthritis: data from two longitudinal cohorts.
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China.
Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7000, Australia.
出版信息
BMC Musculoskelet Disord. 2023 Oct 13;24(1):812. doi: 10.1186/s12891-023-06953-2.
BACKGROUND
Previous studies have been inconsistent concerning the association between smoking and risk of osteoarthritis (OA). This study aimed to explore the associations of smoking status and change in cartilage volume of OA in two longitudinal cohorts.
METHODS
Subjects from the Osteoarthritis Initiative cohort (OAI, n = 593) and the Tasmanian Older Adult Cohort (TASOAC, n = 394) were included in this study. For both cohorts, participants were classified into three groups based on their smoking status, namely 'never', 'former', and 'current' smokers. The outcome measures were the annual rate of change of tibiofemoral cartilage volume over 2 years in OAI and of tibial cartilage volume over 2.6 years in TASOAC. Potential confounders were balanced using the inverse probability of treatment weighting (IPTW) method.
RESULTS
Overall, 42.3% and 37.4% of participants were former smokers, and 5.7% and 9.3% were current smokers in the OAI and TASOAC cohorts, respectively. Compared to never smokers, neither former nor current smoking was associated with risk of the annual rate of change of tibiofemoral cartilage volume in OAI (former smoker: β=-0.068%/year, 95% confidence interval [CI] -0.824 to 0.688, p = 0.860; current smoker: β=-0.222%/year, 95% CI -0.565 to 0.120, p = 0.204) and tibial cartilage volume in TASOAC (former smoker: β = 0.001%/year, 95% CI -0.986 to 0.989, p = 0.998; current smoker: β=-0.839%/year, 95% CI -2.520 to 0.844, p = 0.329).
CONCLUSIONS
Our findings from two independent cohorts consistently showed that smoking was not associated with knee cartilage loss in older adults.
背景
先前的研究对于吸烟与骨关节炎（OA）风险之间的关联结果并不一致。本研究旨在通过两个纵向队列来探讨吸烟状况与 OA 患者软骨体积变化之间的相关性。
方法
本研究纳入了 Osteoarthritis Initiative 队列（OAI，n=593）和塔斯马尼亚老年队列（TASOAC，n=394）中的受试者。对于两个队列，参与者均根据吸烟状况分为三组，即“从不”、“曾经”和“当前”吸烟者。主要结局测量指标为 OAI 中 2 年内的胫股关节软骨体积年变化率和 TASOAC 中 2.6 年内的胫骨软骨体积年变化率。采用逆概率治疗加权（IPTW）法来均衡潜在混杂因素。
结果
OAI 和 TASOAC 队列中，分别有 42.3%和 37.4%的参与者为曾经吸烟者，5.7%和 9.3%的参与者为当前吸烟者。与从不吸烟者相比，OAI 中当前或曾经吸烟者的胫股关节软骨体积年变化率风险均无显著相关性（曾经吸烟者：β=-0.068%/年，95%置信区间[CI] -0.824 至 0.688，p=0.860；当前吸烟者：β=-0.222%/年，95%CI -0.565 至 0.120，p=0.204），TASOAC 中胫骨软骨体积年变化率也无显著相关性（曾经吸烟者：β=0.001%/年，95%CI -0.986 至 0.989，p=0.998；当前吸烟者：β=-0.839%/年，95%CI -2.520 至 0.844，p=0.329）。
结论
来自两个独立队列的研究结果一致表明，吸烟与老年人膝关节软骨丢失无关。
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