State Key Laboratory of Oral Diseases, Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences, Sichuan University, 3rd Section of Ren Min Nan Rd, Chengdu, 610041, Sichuan, P. R. China.
Emergency Department, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Chinese Academy of Medical Sciences, Sichuan University, Chengdu, 610041, Sichuan, P. R. China.
BMC Oral Health. 2023 Oct 13;23(1):754. doi: 10.1186/s12903-023-03417-w.
Multiple epidemiological studies have posited a potential association between sleep quality and the risk of oral diseases, yet the resulting conclusions have remained contentious, and the presence of a causal link remains equivocal. In this study, we aimed to investigate the causal relationship between sleep duration, insomnia, and common oral diseases.
We utilized genetic correlation and two-sample Mendelian randomization analyses based on summary statistics from genome-wide association studies of sleep duration (N = 460,099), insomnia (N = 462,341), mouth ulcer (N = 385,026), oral cavity cancer (N = 4,151), and periodontal disease (N = 527,652).
Our results revealed a negative genetic correlation between sleep duration and mouth ulcer (genetic correlation: -0.09, P = 0.007), while a positive genetic correlation between insomnia and mouth ulcer was observed (genetic correlation: 0.18, P = 2.51E-06). Furthermore, we demonstrated that longer sleep duration is significantly associated with a reduced risk of mouth ulcers (OR: 0.67, 95% CI: 0.54-0.83, P = 2.84E-04), whereas insomnia is nominally associated with an increased risk of mouth ulcers (OR: 1.40, 95% CI: 1.01-1.95, P = 0.044). In contrast, no significant association was detected between sleep quality and periodontal disease or oral cavity cancer.
This work provides robust evidence to support the notion that enhanced sleep quality may confer a decreased risk of oral ulcers, thereby bearing considerable clinical relevance.
多项流行病学研究提出，睡眠质量与口腔疾病风险之间可能存在关联，但得出的结论仍存在争议，因果关系仍存在不确定性。在这项研究中，我们旨在调查睡眠持续时间、失眠与常见口腔疾病之间的因果关系。
我们利用基于睡眠持续时间（N=460099）、失眠（N=462341）、口腔溃疡（N=385026）、口腔癌（N=4151）和牙周病（N=527652）全基因组关联研究汇总统计数据的遗传相关性和两样本孟德尔随机化分析。
我们的结果显示，睡眠持续时间与口腔溃疡之间存在负遗传相关性（遗传相关性：-0.09，P=0.007），而失眠与口腔溃疡之间存在正遗传相关性（遗传相关性：0.18，P=2.51E-06）。此外，我们表明，睡眠持续时间较长与口腔溃疡风险降低显著相关（OR：0.67，95%CI：0.54-0.83，P=2.84E-04），而失眠与口腔溃疡风险增加呈名义相关（OR：1.40，95%CI：1.01-1.95，P=0.044）。相比之下，睡眠质量与牙周病或口腔癌之间没有显著关联。
这项工作提供了有力的证据支持这样一种观点，即改善睡眠质量可能降低口腔溃疡的风险，因此具有重要的临床意义。
