Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, the First Affiliated Hospital/Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Department of Pathology, Nanyang Central Hospital, Nanyang, Henan, China.
World J Surg Oncol. 2023 Oct 13;21(1):321. doi: 10.1186/s12957-023-03206-3.
The Parkinson's disease (PD) gene family expression is strongly linked to tumor development and progression; PINK1 and PARK2 are essential members of the PD gene family. However, the relationship between PINK1 and PARK2 and esophageal squamous cell carcinoma (ESCC) remains unknown. This research aims to clarify the prognostic value of PINK1 and PARK2 in ESCC.
PINK1 and PARK2 protein levels in 232 ESCC specimens, and 125 matched adjacent normal tissues were detected by immunohistochemistry. The relationship between PINK1 and PARK2 protein expression and clinicopathological features were analyzed. Kaplan-Meier survival analysis was performed to estimate the prognostic value of the PINK1 and PARK2 proteins in patients. Cox univariate and multivariate analyses were used to assess the risk factors affecting the OS for patients with ESCC.
PINK1 and PARK2 had low expression in ESCC. Patients with low PINK1 had worse differentiation and advanced T and TNM stages. Lower PARK2 expression was linked to lymph node metastases and an advanced TNM stage. Furthermore, reduced PINK1 and PARK2 levels were associated with a poor prognosis for ESCC. Cox univariate and multivariate analyses revealed that PINK1, PARK2, and tumor size were closely associated with the prognosis of patients with ESCC, and PARK2 was an independent risk factor for patients with ESCC. Finally, the PINK1 and PARK2 proteins were closely related and shared the same signal pathway.
PINK1 and PARK2 could work as tumor suppressors in ESCC and are likely to become new treatment targets for ESCC.
帕金森病（PD）基因家族的表达与肿瘤的发生和发展密切相关；PINK1 和 PARK2 是 PD 基因家族的重要成员。然而，PINK1 和 PARK2 与食管鳞状细胞癌（ESCC）之间的关系尚不清楚。本研究旨在阐明 PINK1 和 PARK2 在 ESCC 中的预后价值。
采用免疫组织化学法检测 232 例 ESCC 标本和 125 例配对的相邻正常组织中的 PINK1 和 PARK2 蛋白水平。分析 PINK1 和 PARK2 蛋白表达与临床病理特征的关系。采用 Kaplan-Meier 生存分析评估 PINK1 和 PARK2 蛋白在患者中的预后价值。采用 Cox 单因素和多因素分析评估影响 ESCC 患者 OS 的危险因素。
PINK1 和 PARK2 在 ESCC 中低表达。PINK1 低表达的患者分化较差，T 分期和 TNM 分期较晚。PARK2 低表达与淋巴结转移和较晚的 TNM 分期有关。此外，PINK1 和 PARK2 水平降低与 ESCC 的不良预后相关。Cox 单因素和多因素分析显示，PINK1、PARK2 和肿瘤大小与 ESCC 患者的预后密切相关，PARK2 是 ESCC 患者的独立危险因素。最后，PINK1 和 PARK2 蛋白密切相关，共享相同的信号通路。
PINK1 和 PARK2 可能在 ESCC 中作为肿瘤抑制因子发挥作用，可能成为 ESCC 的新治疗靶点。
