Wei Xiangyun, Li Xiaohe, Hu Shuming, Cheng Jinke, Cai Rong
Department of Biochemistry & Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Int J Mol Sci. 2023 Sep 27;24(19):14614. doi: 10.3390/ijms241914614.
Lung adenocarcinoma (LUAD) is the most common lung cancer, which accounts for about 35-40% of all lung cancer patients. Despite therapeutic advancements in recent years, the overall survival time of LUAD patients still remains poor, especially KRAS mutant LUAD. Therefore, it is necessary to further explore novel targets and drugs to improve the prognos is for LUAD. Ferroptosis, an iron-dependent regulated cell death (RCD) caused by lipid peroxidation, has attracted much attention recently as an alternative target for apoptosis in LUAD therapy. Ferroptosis has been found to be closely related to LUAD at every stage, including initiation, proliferation, and progression. In this review, we will provide a comprehensive overview of ferroptosis mechanisms, its regulation in LUAD, and the application of targeting ferroptosis for LUAD therapy.
肺腺癌（LUAD）是最常见的肺癌，约占所有肺癌患者的35%-40%。尽管近年来治疗取得了进展，但LUAD患者的总体生存时间仍然很差，尤其是KRAS突变型LUAD。因此，有必要进一步探索新的靶点和药物，以改善LUAD的预后。铁死亡是一种由脂质过氧化引起的铁依赖性调节性细胞死亡（RCD），作为LUAD治疗中凋亡的替代靶点，最近受到了广泛关注。已发现铁死亡在LUAD的各个阶段，包括起始、增殖和进展，都与LUAD密切相关。在这篇综述中，我们将全面概述铁死亡机制、其在LUAD中的调节以及靶向铁死亡在LUAD治疗中的应用。
