The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Int J Mol Sci. 2023 Oct 3;24(19):14871. doi: 10.3390/ijms241914871.
Cells are the smallest units that make up living organisms, which constantly undergo the processes of proliferation, differentiation, senescence and death. Dead cells need to be removed in time to maintain the homeostasis of the organism and keep it healthy. This process is called efferocytosis. If the process fails, this may cause different types of diseases. More and more evidence suggests that a faulty efferocytosis process is closely related to the pathological processes of respiratory diseases. In this review, we will first introduce the process and the related mechanisms of efferocytosis of the macrophage. Secondly, we will propose some methods that can regulate the function of efferocytosis at different stages of the process. Next, we will discuss the role of efferocytosis in different lung diseases and the related treatment approaches. Finally, we will summarize the drugs that have been applied in clinical practice that can act upon efferocytosis, in order to provide new ideas for the treatment of lung diseases.
细胞是构成生物体的最小单位，它们不断经历增殖、分化、衰老和死亡的过程。为了维持生物体的内稳态并保持其健康，死亡的细胞需要及时被清除。这个过程被称为噬细胞作用（efferocytosis）。如果这个过程失败，可能会导致不同类型的疾病。越来越多的证据表明，噬细胞作用过程的缺陷与呼吸道疾病的病理过程密切相关。在这篇综述中，我们首先将介绍巨噬细胞噬细胞作用的过程和相关机制。其次，我们将提出一些可以调节该过程不同阶段噬细胞作用功能的方法。接下来，我们将讨论噬细胞作用在不同肺部疾病中的作用以及相关的治疗方法。最后，我们将总结已应用于临床实践中可作用于噬细胞作用的药物，以期为肺部疾病的治疗提供新的思路。
Zotero 插件